Featured Research

from universities, journals, and other organizations

Release of data from Nobel Prize-winning laboratory for public use

Date:
October 23, 2012
Source:
BioMed Central Limited
Summary:
LabArchives, a provider of online lab notebook software, and BioMed Central’s open access journal BMC Research Notes has published Mutagenetix, an online open access repository of ENU-generated data. The data is linked permanently to a ‘Data Note’, describing results from the ENU mutagenesis program, operated by the Beutler laboratory at The Scripps Research Institute in La Jolla, CA and which won them the Nobel Prize in Physiology or Medicine 2011.

LabArchives, a provider of online lab notebook software, and BioMed Central's open access journal BMC Research Notes has published Mutagenetix, an online open access repository of ENU-generated data. The data is linked permanently to a 'Data Note', describing results from the ENU mutagenesis program, operated by the Beutler laboratory at The Scripps Research Institute in La Jolla, CA and which won them the Nobel Prize in Physiology or Medicine 2011.

Related Articles


Over the last decade an ENU mutagenesis program was operated by the Beutler laboratory at The Scripps Research Institute in La Jolla, CA. The laboratory has recently moved to UT Southwestern Medical Center in Dallas, TX, where this work has continued. The aim of this program was to create random, inheritable, mutations and link these mutations to phenotypes, physical characteristics and identifiable disruptions in cellular function. The main focus has centered on the immune system, extending studies of innate and adaptive immunity that won Bruce Beutler, Jules Hoffmann, and Ralph Steinman The Nobel Prize in Physiology or Medicine 2011. However this data set has many more applications throughout biology and medicine.

Through its innovative partnership with LabArchives, a provider of online lab notebook software, BioMed Central's open access journal BMC Research Notes has published Mutagenetix, an online open access repository of ENU-generated data. The data, which underpin the Beutler Lab's discoveries, match gene mutation via location, structure, and function of the mutated protein, to physical and cellular changes in mice. The dataset is published through the LabArchives platform and is linked permanently to a 'Data Note' article published in BMC Research Notes. The Mutagenix database, is available for reuse by other scientists freely, under a Creative Commons waiver. Together these resources can be used to suggest potential mechanisms behind human diseases.

Prof Beutler, explained, "Over a period of eleven years we accumulated hundreds of mutations, induced in the mouse genome using the germ line mutagen ENU. Some of these mutations caused striking phenotypes, and broke new ground in immunology, metabolism, neuroscience, and basic cell biology. In effect, we created many new genetic disease in mice, most of which are also represented in humans. Other mutations were not known to cause phenotypes, and were identified 'incidentally.' He continued, "The dataset we have acquired allows us to make strong inferences about how mutagenesis works. For example, how likely it is that an amino acid change induced by ENU will cause phenotype? Does ENU attack DNA randomly, or is it somewhat biased? Our data also provide the basic information needed to model mutagenesis in vitro, to predict just how many genes will be damaged or destroyed in a given population of mice."

Iain Hrynaszkiewicz, from BioMed Central commented, "This is an excellent example of how valuable publishing datasets with accompanying journal publications can be. As a result of our partnership with LabArchives, data which extend the Beutler lab's Nobel Prize-winning discoveries are available for public use, and the data are put into context with an associated peer-reviewed journal publication in BMC Research Notes. Also, the authors exemplify best practice in linking data to publications and in data citation, which we hope will help motivate more scientists and funders of research to publish their data in an open access environment."

All of the phenotypes and their accompanying mutations are described in detail at http://mutagenetix.utsouthwestern.edu, and in the LabArchives notebook http://dx.doi.org/10.6070/H4VD6WC9.


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central Limited. "Release of data from Nobel Prize-winning laboratory for public use." ScienceDaily. ScienceDaily, 23 October 2012. <www.sciencedaily.com/releases/2012/10/121023204638.htm>.
BioMed Central Limited. (2012, October 23). Release of data from Nobel Prize-winning laboratory for public use. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2012/10/121023204638.htm
BioMed Central Limited. "Release of data from Nobel Prize-winning laboratory for public use." ScienceDaily. www.sciencedaily.com/releases/2012/10/121023204638.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gorilla Falls Into Zoo Moat

Gorilla Falls Into Zoo Moat

Reuters - Light News Video Online (Mar. 31, 2015) A gorilla comes to the rescue of her sister who fell into a moat in Israel&apos;s Safari zoo. Rough cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Giant Amphibian Fossils Found in Portugal

Giant Amphibian Fossils Found in Portugal

Reuters - Light News Video Online (Mar. 31, 2015) Scientists discover a new species of giant amphibian that was one of the largest predators on earth about 220 million year ago. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Rhino Goes on Deadly Rampage in Nepal

Rhino Goes on Deadly Rampage in Nepal

Reuters - News Video Online (Mar. 31, 2015) A rhino runs rampant down a bustling city street, killing one woman and injuring several others, before security personnel chase it back into the forest. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
Bionic Ants Could Be Tomorrow's Factory Workers

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins