Featured Research

from universities, journals, and other organizations

New genetic links for inflammatory bowel disease uncovered

Date:
October 31, 2012
Source:
Broad Institute of MIT and Harvard
Summary:
Researchers from the Crohn's disease and ulcerative colitis communities have come together to share raw data as well as newly collected genetic information to dissect the biology of a group of conditions that affects millions of people. Their research centers on the two diseases, which are collectively known as inflammatory bowel disease and suggests a fundamental connection between risk of IBD and genes involved in other immune-related diseases and the immune system's response to pathogens.

Researchers have identified more than 70 new genetic links (shown as bright spots on chromosomes, shaded in blue) tied to inflammatory bowel disease (IBD).
Credit: Image courtesy of Janet Iwasa and Bang Wong

Crohn's disease (CD) and ulcerative colitis (UC) -- inflammatory diseases of the gastrointestinal tract -- have puzzled the scientific community for decades. Ten years ago, researchers recognized that both genes and the environment contributed to these diseases but knew little about precisely how and why illness occurred. To begin to narrow in on the key pathways involved, they would need thousands of patients' samples, millions of data points, and the commitment of physicians and scientists at dozens of institutions.

Today, researchers from across the CD and UC communities have come together to share raw data as well as newly collected genetic information to dissect the biology of a group of conditions that affects millions of people worldwide. Their research centers on the two diseases, which are collectively known as inflammatory bowel disease (IBD) and suggests a fundamental connection between risk of IBD and genes involved in other immune-related diseases and the immune system's response to pathogens. The work by researchers from the Broad Institute, Massachusetts General Hospital, Yale School of Medicine, Cedars-Sinai Medical Center, and dozens of other organizations appears in a Nature paper this week.

"This study marks the first time we've acquired and combined the raw data from so many research studies around the world and also the first time we've jointly analyzed Crohn's with ulcerative colitis," said author Mark Daly, one of the senior authors of the work and senior associate member of the Broad Institute and co-director of its Program in Medical and Population Genetics. Daly is also chief of the Analytic and Translational Genetics Unit at Massachusetts General Hospital (MGH) and an associate professor at Harvard Medical School. "We've been able, with this study, to evaluate the evidence for both diseases simultaneously, and discovered that the majority of genetic risk factors are associated with both diseases."

"There's been a paradigm shift in our understanding of IBD. This gene discovery process offers an opportunity to begin identifying new targets for treatment, better diagnostic tools, and in the long-term, personalized care for patients," said co-author Ramnik Xavier, a senior associate member of the Broad Institute, Chief of Gastroenterology and Director of the Center for the Study of Inflammatory Bowel Disease at MGH. "We now have the necessary starting material to understand the pathways that contribute to Crohn's disease and ulcerative colitis, and we also have a framework to better appreciate that they may not be two distinct diseases, but rather collections of many different diseases."

Crohn's disease (CD) and ulcerative colitis (UC) share much in common -- both cause many of the same gastrointestinal symptoms and both are marked by an improper response by the body's immune system to harmless cells or bacteria. Over the last ten years, researchers have performed genome-wide association studies, looking across the genomes of thousands of patients with either CD or UC and compared them to genomes from people without these diseases to find significant genetic differences. The new study not only brings together the original data from those previous analyses, but also adds genetic information from another 40,000 people either with or without a form of IBD.

"If we want to get more hits but also dissect the differences between Crohn's disease and ulcerative colitis or understand the commonalities, we really need to share all of our genetic data," said co-first author Stephan Ripke, a researcher at the Broad Institute and MGH. Ripke worked closely with co-first author Luke Jostins of the Sanger Institute to combine and then analyze genetic information collected by researchers from many different institutions.

The new study identified 71 additional genetic associations for IBD, many of which have been previously implicated in other immune-related disorders, including ankylosing spondylitis and psoriasis. The new research also suggests a strong overlap between IBD susceptibility genes and genes tied to the immune system's response to mycobacterial infections, including tuberculosis and leprosy. Researchers have observed similarities between the immune response in CD and that seen in tuberculosis and hypothesize that CD could be an aberrant response to certain harmless organisms present in the gut that trigger a similar reaction.

In addition to drawing upon original data from previous studies, the work utilizes a relatively new tool known as the immunochip, which samples 200,000 sites in the genome previously tied to autoimmune and inflammatory diseases.

"As a research community, we designed this array to target genes involved in immune-mediated diseases of all kinds," said Daly. "This is one of our first studies using the immunochip, and there are many more results that will emerge from these studies -- within IBD and across immune diseases."

At the Broad Institute, researchers are already pursuing some of the pathways identified in previous studies of UC and CD, including autophagy, a process in which infected cells eat themselves to combat microbes.

"This work gives us additional leads to pursue," said Xavier. "It gives us an opportunity for high-quality, translational research, allowing us to identify core pathways involved in IBD and better understand how genes interact with each other and with the environment, illuminating new pathways that contribute to disease."

Other researchers who contributed to this work include Luke Jostins, Rinse K Weersma, Richard H Duerr, Dermot P McGovern, Ken Y Hui, James C Lee, L Philip Schumm, Yashoda Sharma, Carl A Anderson, Jonah Essers, Mitja Mitrovic, Kaida Ning, Isabelle Cleynen, Emilie Theatre, Sarah L Spain, Soumya Raychaudhuri, Philippe Goyette, Zhi Wei, Clara Abraham, Jean-Paul Achkar, Tariq Ahmad, Leila Amininejad , Ashwin N Ananthakrishnan, Vibeke Andersen, Jane M Andrews, Leonard Baidoo, Tobias Balschun, Peter A Bampton, Alain Bitton, Gabrielle Boucher, Stephan Brand, Carsten Bόning, Ariella Cohain, Sven Cichon, Mauro D'Amato, Dirk De Jong, Kathy L Devaney, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Lynnette R Ferguson, Denis Franchimont, Karin Fransen, Richard Gearry, Michel Georges, Christian Gieger, Jόrgen Glas, Talin Haritunians, Ailsa Hart, Chris Hawkey, Matija Hedl, Xinli Hu, Tom H Karlsen, Limas Kupcinskas, Subra Kugathasan, Anna Latiano, Debby Laukens, Ian C Lawrance, Charlie W Lees, Edouard Louis, Gillian Mahy, John Mansfield, Angharad R Morgan, Craig Mowat, William Newman, Orazio Palmieri, Cyriel Y Ponsioen, Uros Potocnik, Natalie J Prescott, Miguel Regueiro, Jerome I Rotter, Richard K Russell, Jeremy D Sanderson, Miquel Sans, Jack Satsangi, Stefan Schreiber, Lisa A Simms, Jurgita Sventoraityte, Stephan R Targan, Kent D Taylor, Mark Tremelling, Hein W Verspaget, Martine De Vos, Cisca Wijmenga, David C Wilson, Juliane Winkelmann, Sebastian Zeissig, Bin Zhang, Clarence K Zhang, Hongyu Zhao, The International IBD Genetics Consortium, Mark S Silverberg, Vito Annese, Hakon Hakonarson, Steven R Brant, Graham Radford-Smith, Christopher G Mathew, John D Rioux, Eric E Schadt, Andre Franke, Miles Parkes, Severine Vermeire, Jeffrey C Barrett, and Judy H Cho.


Story Source:

The above story is based on materials provided by Broad Institute of MIT and Harvard. The original article was written by Haley Bridger. Note: Materials may be edited for content and length.


Journal Reference:

  1. Luke Jostins et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature, 491, 119%u2013124; 01 November 2012 DOI: 10.1038/nature11582

Cite This Page:

Broad Institute of MIT and Harvard. "New genetic links for inflammatory bowel disease uncovered." ScienceDaily. ScienceDaily, 31 October 2012. <www.sciencedaily.com/releases/2012/10/121031141858.htm>.
Broad Institute of MIT and Harvard. (2012, October 31). New genetic links for inflammatory bowel disease uncovered. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2012/10/121031141858.htm
Broad Institute of MIT and Harvard. "New genetic links for inflammatory bowel disease uncovered." ScienceDaily. www.sciencedaily.com/releases/2012/10/121031141858.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins