Featured Research

from universities, journals, and other organizations

Fasting time prior to blood lipid tests appears to have limited association with lipid levels

Date:
November 12, 2012
Source:
JAMA and Archives Journals
Summary:
Fasting prior to blood lipid tests appears to have limited association with lipid subclass levels, suggesting that fasting for routine lipid level determinations may be unnecessary.

Fasting prior to blood lipid tests appears to have limited association with lipid subclass levels, suggesting that fasting for routine lipid level determinations may be unnecessary, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

"Although current guidelines recommend measuring lipid levels in a fasting state, recent studies suggest that nonfasting lipid profiles change minimally in response to food intake and may be superior to fasting levels in predicting adverse cardiovascular outcomes," write Davinder Sidhu, M.D., L.L.B, and Christopher Naugler, M.Sc., M.D., C.C.F.P., F.C.F.P., F.R.C.P.C., with the University of Calgary, Alberta, Canada.

The authors conducted a cross-sectional examination of laboratory data, which included fasting duration (in hours) and lipid results, over a 6-month period in 2011 of a large community-based cohort. A total of 209,180 participants (111,048 women) were included in the analysis.

In general, the authors found that among average cholesterol levels, the mean (average) levels of total cholesterol and high-density lipoprotein (HDL) differed little among individuals with various fasting times. Specifically, these levels varied by less than 2 percent for total cholesterol and HDL cholesterol, less than 10 percent for calculated low-density lipoprotein (LDL) cholesterol, and by less than 20 percent for triglycerides.

"We found that fasting time showed little association with lipid subclass levels in a large community-based cohort," the authors conclude. "This finding suggests that fasting for routine lipid level determinations is largely unnecessary."

Editorial: Should We Fast Before We Measure Our Lipids?

In an accompanying editorial, J. Michael Gaziano, M.D., M.P.H., of Brigham and Women's Hospital,Harvard Medical School and VA Boston Healthcare System, writes: "What are the pros and cons of obtaining a fasting lipid profile? …This question is addressed by Sidhu and Naugler in this issue."

"In summary, most of the reasons that we measure a lipid profile depend on total and HDL cholesterol levels for most of our decision making. The incremental gain in information of a fasting profile is exceedingly small for total and HDL cholesterol values and likely does not offset the logistic impositions placed on our patients, the laboratories, and our ability to provide timely counseling to our patients. This, in my opinion, tips the balance toward relying on nonfasting lipid profiles as the preferred practice," Gaziano concludes.

Commentary: Fasting for Lipid Testing

In an invited commentary, Amit V. Khera, M.D., and Samia Mora, M.D., M.H.S., of Brigham and Women's Hospital and Harvard Medical School, Boston, write: "A report by Sidhu and Naugler in this issue challenges the necessity of fasting before blood collection."

The authors also note that, "a growing body of evidence from observational studies and statin clinical trials suggests that non-fasting or fasting blood draws may be used for cardiovascular risk assessment and therapeutic decisions, especially when lipid subfractions other than LDL-C (e.g., the total HDL-C ratio or non-HDL-C) are emphasized."

"Additional prospective studies that directly compare the association of fasting and nonfasting lipid levels with cardiovascular outcomes in the same individuals would be informative. Further validation studies are needed before a nonfasting lipid testing strategy is universally endorsed," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Fasting time prior to blood lipid tests appears to have limited association with lipid levels." ScienceDaily. ScienceDaily, 12 November 2012. <www.sciencedaily.com/releases/2012/11/121112171316.htm>.
JAMA and Archives Journals. (2012, November 12). Fasting time prior to blood lipid tests appears to have limited association with lipid levels. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2012/11/121112171316.htm
JAMA and Archives Journals. "Fasting time prior to blood lipid tests appears to have limited association with lipid levels." ScienceDaily. www.sciencedaily.com/releases/2012/11/121112171316.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Foods Are Getting Pricier

Breakfast Foods Are Getting Pricier

AP (Apr. 21, 2014) Breakfast is now being served with a side of sticker shock. The cost of morning staples like bacon, coffee and orange juice is on the rise because of global supply problems. (April 21) Video provided by AP
Powered by NewsLook.com
Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins