Featured Research

from universities, journals, and other organizations

Sexual and social behavior modified by serotonin system drugs

Date:
December 11, 2012
Source:
Leiden, Universiteit
Summary:
Drugs that bind to specific serotonin receptors in the brain can both improve and impair female sexual function in non-human primates.

Drugs that bind to specific serotonin receptors in the brain can both improve and impair female sexual function in non-human primates.

Related Articles


These are the findings of a study conducted by Leiden PhD candidate Yves Aubert and colleagues at the division of Medical Pharmacology of the Leiden/Amsterdam Center for Drug Research (LACDR & LUMC).

The common marmoset

Aubert carried out his research in co-operation with the Wisconsin National Primate Research Center at the University of Wisconsin-Madison. 'Relationship dynamics between partners are a key factor in determining female sexual behaviour,' Aubert concludes from experiments conducted in common marmosets, a species of New World monkeys that form long-term pair-bonds similar to those of humans. After treating female marmosets for several weeks with drugs that have specific serotonin receptor binding properties, Aubert was surprised to find not only changes in the females' sexual and social behaviour directed at their male pairmates, but also changes in the males' behaviour towards the females. In an innovative approach, he used two experimental drugs in his experiments that resulted in opposite behavioural effects.

One drug (8-OH-DPAT) had a negative impact on female sexual and social behaviour, while the other had a positive impact, as Aubert demonstrated for the first time in a non-human primate. 'Clearly, pair-bond quality between partners and sexual behaviour are closely linked. While one drug increases aggression between male and female and sexual rejection of the male by the female partner, the other drug increases social grooming between pairmates and enhances the female's sexual attractiveness to her male partner.'

A pharmacotherapeutic treatment option for women suffering from HSDD?

The drug with the positive impact, called Flibanserin, was developed as a potential non-hormonal treatment for pre-menopausal women with hypoactive sexual desire disorder (HSDD). HSDD is the most commonly reported female sexual complaint and is characterised by a persistent lack of sexual fantasies or desire that causes marked personal distress and/or personal difficulties. Aubert suggests that Flibanserin's therapeutic effects in women with HSDD may stem from improvements in sexual, social and emotional bonding between partners.

Unraveling the neurobiology of female sexual behaviour

Using a monkey model provided the researchers with the opportunity to ask detailed questions about the neurobiological underpinnings of female sexual behaviour. Aubert and his teams of researchers in Madison (Wisconsin, U.S.A.) and in Leiden conducted endocrine, imaging and genetic experiments to learn about hormonal and brain activity and gene expression patterns that are involved in the processes leading to impaired or improved female sexual and social behaviour. 'I believe that our results provide new leads and may spur renewed interest in the study of female sexual function -- a topic that has been a taboo, or marginalised, for too long,' comments Aubert. 'Our study suggests that oxytocin may be the pivot of serotonergic regulation of female sexual behaviour, pair-bond and pharmacotherapy of HSDD; a finding that warrants attention in future studies.'


Story Source:

The above story is based on materials provided by Leiden, Universiteit. Note: Materials may be edited for content and length.


Cite This Page:

Leiden, Universiteit. "Sexual and social behavior modified by serotonin system drugs." ScienceDaily. ScienceDaily, 11 December 2012. <www.sciencedaily.com/releases/2012/12/121211083033.htm>.
Leiden, Universiteit. (2012, December 11). Sexual and social behavior modified by serotonin system drugs. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2012/12/121211083033.htm
Leiden, Universiteit. "Sexual and social behavior modified by serotonin system drugs." ScienceDaily. www.sciencedaily.com/releases/2012/12/121211083033.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Arthropod Fossil Might Be Relative Of Spiders, Scorpions

New Arthropod Fossil Might Be Relative Of Spiders, Scorpions

Newsy (Mar. 29, 2015) A 508-million-year-old arthropod that swam in the Cambrian seas is thought to share a common ancestor with spiders and scorpions. Video provided by Newsy
Powered by NewsLook.com
Vietnam Rice Boom Piles Pressure on Farmers and the Environment

Vietnam Rice Boom Piles Pressure on Farmers and the Environment

AFP (Mar. 29, 2015) Vietnam&apos;s drive to become the world&apos;s leading rice exporter is pushing farmers in the fertile Mekong Delta to the brink, say experts, with mounting costs to the environment. Duration: 02:35 Video provided by AFP
Powered by NewsLook.com
Raw: Lioness Has Rare Five-Cub Litter

Raw: Lioness Has Rare Five-Cub Litter

AP (Mar. 27, 2015) A lioness in Pakistan has given birth to five cubs, twice the usual size of a litter. Queen gave birth to two other cubs just nine months ago. (March 27) Video provided by AP
Powered by NewsLook.com
Jockey Motion Tracking Reveals Racing Prowess

Jockey Motion Tracking Reveals Racing Prowess

Reuters - Innovations Video Online (Mar. 26, 2015) Using motion tracking technology, researchers from the Royal Veterinary College (RVC) are trying to establish an optimum horse riding style to train junior jockeys, as well as enhance safety, health and well-being of both racehorses and jockeys. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins