Featured Research

from universities, journals, and other organizations

Evidence supports blocking immune response to enhance viral therapy against solid tumors

Date:
March 13, 2013
Source:
Nationwide Children's Hospital
Summary:
Following several years of study, investigators have found more evidence that viral therapy to treat solid tumors can be enhanced by blocking the body's natural immune response.

Following several years of study, investigators have found more evidence that viral therapy to treat solid tumors can be enhanced by blocking the body's natural immune response.

Oncolytic viruses have shown promise as anticancer agents, with variations of the herpes simplex virus (HSV) among the most commonly used. However, many studies have shown that the effectiveness of viral therapy to eradicate tumors has not been as successful with patients as it has been in the lab. These results have led researchers to examine the body's immune system response to determine what effect it may have toward decreasing the effectiveness of viral therapy.

A new study, published in the March 12, 2013 issue of Molecular Therapy and led by Timothy Cripe, MD, PhD, division chief of Hematology/Oncology and Bone Marrow Transplantation at Nationwide Children's Hospital, is shedding additional light on how viral therapy combined with a suppressed immune response could be more effective against solid tumors.

Dr. Cripe and a team of investigators studied the effects of vascular endothelial growth factor (VEGF), a substance commonly released during an immune, or pro-inflammatory, response to a viral infection. VEGF is responsible for angiogenesis, new blood vessel growth near an injured or infected site.

VEGF is also important for tumor growth, raising the possibility that its response to virus infection might get in the way of viral therapy.

"We sought to determine if a pro-angiogenic response occurs during viral therapy for cancer, to what extent it may limit antitumor effectiveness, and if it could be counteracted by antiangiogenic therapy," explains Dr. Cripe, who is also a professor of Pediatrics at The Ohio State University College of Medicine.

Their research demonstrates that an anti-VEGF antibody markedly enhances the anti-tumor effect of an oncolytic virus (oHSV) injected into a tumor. They also discovered that the anti-tumor effect was due to both enhanced antiangiogenesis and the modulation of the tumor's immune response. However the effect was not due to the virus replicating within the tumor.

"One of the most important outcomes of this study is the strong rationale for developing a clinical trial combining the use of oHSV and the FDA-approved anti-VEGF product, bevacizumab," said Dr. Cripe. "Virus therapy or anti-VEGF therapy alone each independently prolonged survival of mouse models implanted with Ewing sarcoma, but all of those mice eventually succumbed to their cancer. In contrast, the combination of virus and anti-VEGF therapies cured 90 percent of the mice. Virus therapy is a very promising area of cancer treatment, and studies such as these will bring us even closer to success."

Future studies will be developed to determine if immune responses vary among tumor types and if targeted therapy for specific aspects of the immune response will be more effective than completely suppressing the immune system.


Story Source:

The above story is based on materials provided by Nationwide Children's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark A Currier, Francis K Eshun, Allyson Sholl, Artur Chernoguz, Kelly Crawford, Senad Divanovic, Louis Boon, William F Goins, Jason S Frischer, Margaret H Collins, Jennifer L Leddon, William H Baird, Amy Haseley, Keri A Streby, Pin-Yi Wang, Brett W Hendrickson, Rolf A Brekken, Balveen Kaur, David Hildeman, Timothy P Cripe. VEGF Blockade Enables Oncolytic Cancer Virotherapy in Part by Modulating Intratumoral Myeloid Cells. Molecular Therapy, 2013; DOI: 10.1038/mt.2013.39

Cite This Page:

Nationwide Children's Hospital. "Evidence supports blocking immune response to enhance viral therapy against solid tumors." ScienceDaily. ScienceDaily, 13 March 2013. <www.sciencedaily.com/releases/2013/03/130313123542.htm>.
Nationwide Children's Hospital. (2013, March 13). Evidence supports blocking immune response to enhance viral therapy against solid tumors. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2013/03/130313123542.htm
Nationwide Children's Hospital. "Evidence supports blocking immune response to enhance viral therapy against solid tumors." ScienceDaily. www.sciencedaily.com/releases/2013/03/130313123542.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins