Featured Research

from universities, journals, and other organizations

How proteins read meta DNA code

Date:
March 19, 2013
Source:
Springer Science+Business Media
Summary:
Scientists have accurately calculated the sliding mechanism for deciphering the second genetic code written within the DNA base pair sequence.

Scientists have accurately calculated the sliding mechanism for deciphering the second genetic code written within the DNA base pair sequence.

Related Articles


Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read by such proteins. Now, Arman Fathizadeh, a physicist at Sharif University of Technology in Tehran, Iran, and colleagues have created a model showing how proteins move along DNA, in a paper just published in EPJ E.

The problem is that until now, we did not clearly understand the physical mechanisms of how to "open the book" to read the genetic text contained in DNA. Studying the dynamics of the nucleosome over reasonable time scales by means of molecular dynamics simulations is out of the question, as it would be too complex. Instead, the authors developed a basic computer model of the nucleosome in which DNA is described by a sequence of rigid blocks representing the base pairs. By introducing flexible binding sites of the DNA to the protein core, it provides a more physical representation of the system.. It also makes it possible to identify the sliding mechanism of nucleosomes along the DNA.

The idea is that a small defect in the form of a missing or extra base pair enters the DNA section wrapped around a nucleosome. This defect can then diffuse through the wrapped DNA and once it leaves the other end of the wrapped section, the nucleosome moves by the extra or missing length that the defect carried with it. This model supports the idea of a second genetic code, previously suggested in 2006. This would consist of a mechanical code written down within the base pair sequence and multiplexed with the traditional genetic code.


Story Source:

The above story is based on materials provided by Springer Science+Business Media. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arman Fathizadeh, Azim Berdy Besya, Mohammad Reza Ejtehadi, Helmut Schiessel. Rigid-body molecular dynamics of DNA inside a nucleosome. The European Physical Journal E, 2013; 36 (3) DOI: 10.1140/epje/i2013-13021-4

Cite This Page:

Springer Science+Business Media. "How proteins read meta DNA code." ScienceDaily. ScienceDaily, 19 March 2013. <www.sciencedaily.com/releases/2013/03/130319091256.htm>.
Springer Science+Business Media. (2013, March 19). How proteins read meta DNA code. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2013/03/130319091256.htm
Springer Science+Business Media. "How proteins read meta DNA code." ScienceDaily. www.sciencedaily.com/releases/2013/03/130319091256.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Drinks for Your Health

The Best Drinks for Your Health

Buzz60 (Feb. 27, 2015) When it comes to health and fitness, there&apos;s lots of talk about what foods to eat, but there are a few liquids that can promote good nutrition. Krystin Goodwin (@krystingoodwin) has the healthiest drinks to boost your health! Video provided by Buzz60
Powered by NewsLook.com
Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The Amazon Keeps Its Green Thanks To The Sahara Desert

The Amazon Keeps Its Green Thanks To The Sahara Desert

Newsy (Feb. 25, 2015) Satellite data shows the Amazon rainforest supports its lush flora with a little help from Sahara Desert dust. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins