Featured Research

from universities, journals, and other organizations

Why some don't respond to rubella vaccine

Date:
May 1, 2013
Source:
Mayo Clinic
Summary:
Using advanced genetic sequencing technology and analysis, vaccine researchers have identified 27 genes that respond in very different ways to the standard rubella vaccine, making the vaccine less effective for a portion of the population.

Using advanced genetic sequencing technology and analysis, Mayo Clinic vaccine researchers have identified 27 genes that respond in very different ways to the standard rubella vaccine, making the vaccine less effective for a portion of the population.

The findings appear today in the online journal PLOS ONE.

"This study highlighted the genes potentially responsible for poor response to the rubella vaccine," says Mayo Clinic vaccinologist Gregory Poland, M.D. "We found differences in genes responsible for antigen interactions, inflammation and differences in the gene pathways involved between low and high vaccine responders. It's another instance of using individualized medicine approaches to find potential solutions for patients not benefiting from standard treatments."

Researchers in the Mayo Clinic Vaccine Research Group began with a random sample of 738 healthy children and young adults who had had two doses of the MMR (measles, mumps, and rubella) vaccine and then selected 25 individuals who represented either high or low responders. Samples from those participants were subject to sequencing of messenger RNA, resulting in transcriptional data that was analyzed for differences in gene expression.

This was the first Next Generation (high-speed, high-throughput) gene expression profiling and analysis conducted after rubella vaccination that provided quantitative data. Researchers say the findings will help in efforts to better understand reactions to the existing rubella vaccine and be very useful in developing alternative vaccines so individuals in the low-response group can be adequately protected.

Co-authors on the study include Iana Haralambieva, M.D., Ph.D.; Ann Oberg, Ph.D.; Inna Ovsyannikova, Ph.D.; Richard Kennedy, Ph.D.; Diane Grill, Sumit Middha, Brian Bot, Vivian Wang, Ph.D.; David I. Smith, Ph.D.; and Robert Jacobson, M.D., all of Mayo Clinic.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Iana H. Haralambieva, Ann L. Oberg, Inna G. Ovsyannikova, Richard B. Kennedy, Diane E. Grill, Sumit Middha, Brian M. Bot, Vivian W. Wang, David I. Smith, Robert M. Jacobson, Gregory A. Poland. Genome-Wide Characterization of Transcriptional Patterns in High and Low Antibody Responders to Rubella Vaccination. PLoS ONE, 2013; 8 (5): e62149 DOI: 10.1371/journal.pone.0062149

Cite This Page:

Mayo Clinic. "Why some don't respond to rubella vaccine." ScienceDaily. ScienceDaily, 1 May 2013. <www.sciencedaily.com/releases/2013/05/130501192924.htm>.
Mayo Clinic. (2013, May 1). Why some don't respond to rubella vaccine. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/05/130501192924.htm
Mayo Clinic. "Why some don't respond to rubella vaccine." ScienceDaily. www.sciencedaily.com/releases/2013/05/130501192924.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins