Featured Research

from universities, journals, and other organizations

Why some don't respond to rubella vaccine

Date:
May 1, 2013
Source:
Mayo Clinic
Summary:
Using advanced genetic sequencing technology and analysis, vaccine researchers have identified 27 genes that respond in very different ways to the standard rubella vaccine, making the vaccine less effective for a portion of the population.

Using advanced genetic sequencing technology and analysis, Mayo Clinic vaccine researchers have identified 27 genes that respond in very different ways to the standard rubella vaccine, making the vaccine less effective for a portion of the population.

Related Articles


The findings appear today in the online journal PLOS ONE.

"This study highlighted the genes potentially responsible for poor response to the rubella vaccine," says Mayo Clinic vaccinologist Gregory Poland, M.D. "We found differences in genes responsible for antigen interactions, inflammation and differences in the gene pathways involved between low and high vaccine responders. It's another instance of using individualized medicine approaches to find potential solutions for patients not benefiting from standard treatments."

Researchers in the Mayo Clinic Vaccine Research Group began with a random sample of 738 healthy children and young adults who had had two doses of the MMR (measles, mumps, and rubella) vaccine and then selected 25 individuals who represented either high or low responders. Samples from those participants were subject to sequencing of messenger RNA, resulting in transcriptional data that was analyzed for differences in gene expression.

This was the first Next Generation (high-speed, high-throughput) gene expression profiling and analysis conducted after rubella vaccination that provided quantitative data. Researchers say the findings will help in efforts to better understand reactions to the existing rubella vaccine and be very useful in developing alternative vaccines so individuals in the low-response group can be adequately protected.

Co-authors on the study include Iana Haralambieva, M.D., Ph.D.; Ann Oberg, Ph.D.; Inna Ovsyannikova, Ph.D.; Richard Kennedy, Ph.D.; Diane Grill, Sumit Middha, Brian Bot, Vivian Wang, Ph.D.; David I. Smith, Ph.D.; and Robert Jacobson, M.D., all of Mayo Clinic.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Iana H. Haralambieva, Ann L. Oberg, Inna G. Ovsyannikova, Richard B. Kennedy, Diane E. Grill, Sumit Middha, Brian M. Bot, Vivian W. Wang, David I. Smith, Robert M. Jacobson, Gregory A. Poland. Genome-Wide Characterization of Transcriptional Patterns in High and Low Antibody Responders to Rubella Vaccination. PLoS ONE, 2013; 8 (5): e62149 DOI: 10.1371/journal.pone.0062149

Cite This Page:

Mayo Clinic. "Why some don't respond to rubella vaccine." ScienceDaily. ScienceDaily, 1 May 2013. <www.sciencedaily.com/releases/2013/05/130501192924.htm>.
Mayo Clinic. (2013, May 1). Why some don't respond to rubella vaccine. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/05/130501192924.htm
Mayo Clinic. "Why some don't respond to rubella vaccine." ScienceDaily. www.sciencedaily.com/releases/2013/05/130501192924.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins