Featured Research

from universities, journals, and other organizations

Epigenetic biomarkers may predict if a specific diet and exercise regimen will work

Date:
May 30, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
Would you try a diet and exercise regimen knowing in advance it would actually help you lose weight? New research shows that this could become reality. Scientists have identified five epigenetic biomarkers in adolescents associated with better weight loss at the beginning of a weight loss program. This could help predict an individual's response to weight loss intervention, and offer targets for enhancing a weight loss program's effects.

Would you be more likely to try a diet and exercise regimen if you knew in advance if it would actually help you lose weight? Thanks to a new report published in the June 2013 issue of The FASEB Journal, this could become a reality. In the report, scientists identify five epigenetic biomarkers in adolescents that were associated with a better weight loss at the beginning of a weight loss program. Not only could this could ultimately help predict an individual's response to weight loss intervention, but it may offer therapeutic targets for enhancing a weight loss program's effects.

"Successful obesity treatment during adolescence could reduce morbidity at later stages of life and lead to a better quality of life," said Amelia Martν, Ph.D., Pharm. D., co-author of this study from the Department of Nutrition, Food Science, Physiology and Toxicology at the University of Navarra in Pamplona, Spain. "It is crucial to find new markers for obesity treatment. Here, we describe five putative epigenetic biomarkers that could help to predict the response to a weight loss intervention in obese adolescents."

To make this discovery, Martν and colleagues first performed a global methylation assay in 24 adolescents who had the best and worst response to the EVASYON weight loss program, and then expanded the sample to include 83 more adolescents. Researchers measured an epigenetic marker, DNA methylation levels, in obese adolescents from a blood sample at baseline and again at the end of the 10-week program. Participants were then divided into two groups (high and low responders) according to the weight loss achieved. The researchers found that the baseline DNA methylation levels of five epigenetic markers were associated with better weight loss response. This EVASYON program is a lifestyle and nutritional educational weight loss program that includes a multidisciplinary team of nutritionists, physiotherapists, psychologists and pediatricians. EVASYON was conducted in five Spanish cities: Granada, Madrid, Pamplona, Santander and Zaragoza.

"If you've ever wondered why some people seem to do so well on a diet and exercise plan and other fail so miserably, then now we know that the way that genes express themselves (via epigenetics) plays an important role," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report moves us a step closer when we will be able to prescribe a weight loss program tailored to more than just the lifestyle and conditioning level of the patient, but also to his or her particular genetic and epigenetic profile."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Moleres, J. Campion, F. I. Milagro, A. Marcos, C. Campoy, J. M. Garagorri, S. Gomez-Martinez, J. A. Martinez, M. C. Azcona-Sanjulian, A. Marti. Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study. The FASEB Journal, 2013; 27 (6): 2504 DOI: 10.1096/fj.12-215566

Cite This Page:

Federation of American Societies for Experimental Biology. "Epigenetic biomarkers may predict if a specific diet and exercise regimen will work." ScienceDaily. ScienceDaily, 30 May 2013. <www.sciencedaily.com/releases/2013/05/130530094950.htm>.
Federation of American Societies for Experimental Biology. (2013, May 30). Epigenetic biomarkers may predict if a specific diet and exercise regimen will work. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/05/130530094950.htm
Federation of American Societies for Experimental Biology. "Epigenetic biomarkers may predict if a specific diet and exercise regimen will work." ScienceDaily. www.sciencedaily.com/releases/2013/05/130530094950.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins