Featured Research

from universities, journals, and other organizations

New way to improve antibiotic production

Date:
June 17, 2013
Source:
Norwich BioScience Institutes
Summary:
New research findings could reduce production times and therefore costs for antibiotic producers.

The antibiotic planosporicin is produced by the soil bacterium Planomonospora alba.
Credit: Image courtesy of Norwich BioScience Institutes

An antibiotic has been found to stimulate its own production. The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.

Scientists Dr Emma Sherwood and Professor Mervyn Bibb from the John Innes Centre were able to use their discovery of how the antibiotic is naturally produced to markedly increase the level of production.

"We have shown for the first time that an antibiotic with clinical potential can act as signalling molecule to trigger its own synthesis," said Professor Bibb.

The antibiotic called planosporicin is produced by a soil bacterium called Planomonospora alba. When nutrients become limited, a small amount of the antibiotic is produced. The antibiotic is then able to trigger a mechanism which coordinates its own production throughout the bacterial population resulting in high levels.

"A frequent stumbling block in developing a natural product for commercialisation is being able to provide enough material for clinical trials," said Professor Bibb.

"Our work shows with the right understanding it is possible to increase productivity very dramatically in a targeted and knowledge-based manner."

With knowledge of this signalling mechanism in hand, the scientists were able to increase production by overexpressing two positively acting regulatory genes and deleting one that acts negatively. Planosporicin is similar to the antibiotic NAI-107 that is about to enter clinical trials for Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) infections. The knowledge gained from this study is being used to increase NAI-107 production.

Commercial manufacturers of antibiotics may be able to use the results to reduce production times and therefore reduce costs. Bacteria often have to be grown for days and sometimes weeks before they start to make effective amounts of an antibiotic. Sherwood and Bibb were able to trigger production essentially from the beginning of growth.

The work was funded through JIC's core strategic grant from the Biotechnology and Biological Sciences Research Council.


Story Source:

The above story is based on materials provided by Norwich BioScience Institutes. Note: Materials may be edited for content and length.


Journal Reference:

  1. Emma J. Sherwood and Mervyn J. Bibb. The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba. PNAS, June 17, 2013 DOI: 10.1073/pnas.1305392110

Cite This Page:

Norwich BioScience Institutes. "New way to improve antibiotic production." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617160900.htm>.
Norwich BioScience Institutes. (2013, June 17). New way to improve antibiotic production. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2013/06/130617160900.htm
Norwich BioScience Institutes. "New way to improve antibiotic production." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617160900.htm (accessed October 23, 2014).

Share This



More Plants & Animals News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Working Mother DIY: Pumpkin Pom-Pom

Working Mother DIY: Pumpkin Pom-Pom

Working Mother (Oct. 22, 2014) How to make a pumpkin pom-pom. Video provided by Working Mother
Powered by NewsLook.com
San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

Reuters - Light News Video Online (Oct. 22, 2014) The pair of rare white northern rhinos bring hope for their species as only six remain in the world. Elly Park reports. Video provided by Reuters
Powered by NewsLook.com
Raw: Bear Cub Strolls Through Oregon Drug Store

Raw: Bear Cub Strolls Through Oregon Drug Store

AP (Oct. 22, 2014) Shoppers at an Oregon drug store were surprised by a bear cub scurrying down the aisles this past weekend. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Family Pleads for Pet Pig to Stay at Home

Family Pleads for Pet Pig to Stay at Home

AP (Oct. 22, 2014) The Johnson family lost their battle with the Chesterfield County, Virginia Planning Commission to allow Tucker, their pet pig, to stay in their home, but refuse to let the board keep Tucker away. (Oct. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins