Featured Research

from universities, journals, and other organizations

Autophaser improves sample analysis in areas such as cancer, Alzheimer's and oil spills

Date:
June 20, 2013
Source:
University of Warwick
Summary:
A new software package allows researchers to vastly improve the performance of one of the key tools used to analyse medical and environmental samples.

A new software package allows researchers to vastly improve the performance of one of the key tools used to analyse medical and environmental samples.

Autophaser, developed by the University of Warwick and Aberystwyth University, enables researchers to make use of significantly more data when using Fourier transform ion cyclotron resonance mass spectrometers (FT-ICR MS).

FT-ICR is a powerful tool for identifying chemicals and biochemical components in complex mixtures and is used by scientists analysing substances across a wide range of sectors including medical, environmental, and commercial areas such as the petroleum industry.

The software, which is free for academic purposes, will allow much greater confidence in interpreting results. For commercial purposes, the software is available to licence from Warwick Ventures, the commercial arm of the University of Warwick.

The normal method of processing data from FT-ICR MS -- magnitude mode -- effectively ignores half of the information generated, so mass accuracy and resolution are not as high as they could be.

However Autophaser allows researchers to make use of this otherwise discarded data by converting FT-ICR MS results to absorption mode. This gives an improvement in spectral resolution of up to three times and a 41% improvement in the signal-to-noise ratio.

Using Autophaser, researchers will see more peaks in the spectrum, get better sequence coverage in proteins and have more confidence in peak assignments.

Dr David Kilgour of the Department of Chemistry at the University of Warwick said: "Major decisions are made every day in commercial, medical, and environmental settings on the basis of FT-ICR MS so it's vital that researchers have access to the most accurate processing methods.

"Autophaser unleashes the full potential of this type of mass spectrometry and really pushes back the barriers to the kinds of problems it can tackle.

"By making this software available for free to academic researchers, we envisage its benefits will be felt across many biomedical areas, for example cancer, Alzheimer's, and Parkinson's, the pharmaceutical and polymer industries, as well as in environmental analysis such as detecting pollution after oil spills."

Although the advantages of absorption mode FT-ICR MS have been known for nearly 40 years, the technique is still not widely used because a key mathematical hurdle presented a barrier.

The researchers at the University of Warwick and Aberystwyth University solved the problem using a kind of artificial intelligence known as a genetic algorithm.

The research behind the software was conducted by David Kilgour and Peter O'Connor at the University of Warwick and Mark Neal at Aberystwyth University; based on earlier work by Peter O'Connor and a student in his group, Yulin Qi.

Autophaser was recently presented at the American Society for Mass Spectrometry annual conference in the US.


Story Source:

The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.


Cite This Page:

University of Warwick. "Autophaser improves sample analysis in areas such as cancer, Alzheimer's and oil spills." ScienceDaily. ScienceDaily, 20 June 2013. <www.sciencedaily.com/releases/2013/06/130620111206.htm>.
University of Warwick. (2013, June 20). Autophaser improves sample analysis in areas such as cancer, Alzheimer's and oil spills. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/06/130620111206.htm
University of Warwick. "Autophaser improves sample analysis in areas such as cancer, Alzheimer's and oil spills." ScienceDaily. www.sciencedaily.com/releases/2013/06/130620111206.htm (accessed October 21, 2014).

Share This



More Computers & Math News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Japanese Scientists Unveil Floating 3D Projection

Japanese Scientists Unveil Floating 3D Projection

Reuters - Innovations Video Online (Oct. 20, 2014) Scientists in Tokyo have demonstrated what they say is the world's first 3D projection that floats in mid air. A laser that fires a pulse up to a thousand times a second superheats molecules in the air, creating a spark which can be guided to certain points in the air to shape what the human eye perceives as an image. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Apple Enters Mobile Payment Business

Apple Enters Mobile Payment Business

AP (Oct. 20, 2014) Apple is making a strategic bet with the launch of Apple Pay, the mobile pay service aimed at turning your iPhone into your wallet. (Oct. 20) Video provided by AP
Powered by NewsLook.com
Google To Protect Against Piracy ... At A Cost

Google To Protect Against Piracy ... At A Cost

Newsy (Oct. 20, 2014) Google is changing its search-engine results to protect content producers from piracy — for a price. Video provided by Newsy
Powered by NewsLook.com
What We Know About Microsoft's Rumored Smartwatch

What We Know About Microsoft's Rumored Smartwatch

Newsy (Oct. 20, 2014) Microsoft will reportedly release a smartwatch that works across different mobile platforms, has a two-day battery life and tracks heart rate. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins