Featured Research

from universities, journals, and other organizations

Natural pest control protein effective against hookworm: A billion could benefit

Date:
July 23, 2013
Source:
American Society for Microbiology
Summary:
A benign crystal protein, produced naturally by bacteria and used as an organic pesticide, could be a safe, inexpensive treatment for parasitic worms in humans and provide effective relief to over a billion people around the world.

A benign crystal protein, produced naturally by bacteria and used as an organic pesticide, could be a safe, inexpensive treatment for parasitic worms in humans and provide effective relief to over a billion people around the world. Researchers from the University of California, San Diego, La Jolla, CA, report on this potentially promising solution in a study published ahead of print in the journal Applied and Environmental Microbiology.

Related Articles


Hookworms, and other intestinal parasites known as helminths infect more than 1 billion people in poverty-stricken, tropical nations, sucking the vitality from the body, and leaving hundreds of millions of children physically and mentally stunted. Current drugs are insufficiently effective, and resistance is rising, but little effort has been made to develop better drugs because the relevant populations do not represent a profitable market for drug companies.

"The challenge is that any cure must be very cheap, it must have the ability to be mass produced in tremendous quantities, safe, and able to withstand rough conditions, including lack of refrigeration, extreme heat, and remote locations," says Raffi Aroian, a researcher on the study.

In earlier research, Aroian and his collaborators described a protein, Cry5B, that can kill intestinal nematode parasites -- such as human hookworms -- in infected test animals (hamsters). Cry5B belongs to a family of proteins that are generally accepted as safe for humans. These proteins are produced naturally in Bacillus thuringiensis (Bt), a bacterium which is applied to crops as a natural insecticide on some organic farms, and CryB proteins have been engineered into food crops such as corn and rice, to render them pest resistant.

As shown for the first time in this paper, Cry5B can also be expressed in a species of bacterium, Bacillus subtilis, which is closely related to Bacillus thuringiensis, and which is also related to bacteria which are present in some probiotics, says Aroian. In the current research researchers showed that a small dose of Cry5B, expressed in this bacterium can achieve a 93 percent elimination of hookworm parasites from infected hamsters. That, says Aroian, is substantially better than current drugs.

The scientific significance of the research, he says, is that "bacteria similar to those that are food grade -- which are cheap and can readily be mass produced--can be engineered to produce molecules that can cure parasitic diseases."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Hu, M. M. Miller, A. I. Derman, B. L. Ellis, R. G. Monnerat, J. Pogliano, R. V. Aroian. A Bacillus subtilis strain engineered for treatment of soil-transmitted helminth diseases. Applied and Environmental Microbiology, 2013; DOI: 10.1128/AEM.01854-13

Cite This Page:

American Society for Microbiology. "Natural pest control protein effective against hookworm: A billion could benefit." ScienceDaily. ScienceDaily, 23 July 2013. <www.sciencedaily.com/releases/2013/07/130723134433.htm>.
American Society for Microbiology. (2013, July 23). Natural pest control protein effective against hookworm: A billion could benefit. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2013/07/130723134433.htm
American Society for Microbiology. "Natural pest control protein effective against hookworm: A billion could benefit." ScienceDaily. www.sciencedaily.com/releases/2013/07/130723134433.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins