Featured Research

from universities, journals, and other organizations

Hamster genome decoded: Researchers successfully sequence genome of Chinese hamster

Date:
August 21, 2013
Source:
Universitaet Bielefeld
Summary:
Genome researchers have succeeded in sequencing the genome of the Chinese hamster. The Chinese hamster supplies the cell cultures used by the pharmaceutical industry to produce biopharmaceutical products such as antibodies used in medicine.

The genome sequencing started with the Chinese hamster (picture).
Credit: Bielefeld University

Genome researchers from Bielefeld University's Center for Biotechnology (CeBiTec) headed by Professor Dr. Alfred Pühler have succeeded in sequencing the genome of the Chinese hamster. The Chinese hamster supplies the cell cultures used by the pharmaceutical industry to produce biopharmaceutical products such as antibodies used in medicine. This costly project was only possible thanks to a cooperation between Bielefeld University and its international project partners.

The researchers have now published their results in the internationally scientific journal Nature Biotechnology.

To carry out this project, the CeBiTec research team cooperated with the University of Natural Resources and Life Sciences in Vienna (where the project was headed by Professor Dr. Nicole Borth), the Austrian Centre of Industrial Biotechnology (acib), and two pharmaceutical companies: Novartis (in Switzerland) and Pfizer (in the USA).

Professor Dr. Thomas Noll, Scientific Director of CeBiTec, is confident that the data they have obtained will be of great interest to science and industry. 'In future, the decoded hamster genome will greatly advance the use of cell lines to produce pharmaceuticals', says Noll, who runs the Cell Culture Technology research group at the Faculty of Technology and participated in the research project.

The genome of the Chinese hamster is composed of eleven pairs of chromosomes. Decoding such a large genome calls for the generation of large datasets that then have to be processed with bioinformatics. To facilitate the resulting data analysis, the researchers in Bielefeld and their colleagues in this project applied a completely new procedure that sorts the single chromosomes of the genome. The sequencing of the hamster chromosomes was performed by Dr. Karina Brinkrolf at CeBiTec. More than 1.4 billion short DNA sequences were generated with the help of modern instruments for next-generation sequencing.

'The major challenge in this project was subsequently piecing these short DNA sequences together to form single total sequences of chromosomes', explains the head of the project Professor Alfred Pühler. This work can only be done with powerful computers. 'We had to complete the new CeBiTec computer cluster and apply new software before we could determine the genome sequence', says the bioinformatics expert Dr. Alexander Goesmann who also worked on the project. 'By decoding the hamster genome sequence', notes Goesmann, 'bioinformatics at Bielefeld University has broken new ground.' With approximately 2.3 billion bases, the magnitude of the genome sequence of the Chinese hamster is comparable to that of the human genome.

The head of the project Alfred Pühler views this research as a milestone in the work at CeBiTec: 'The decoding of the hamster genome successfully concludes a major CeBiTec project. The hamster sequence is available in the public domain and can be used for research throughout the world.' The project greatly enhances the status of Bielefeld as a basis for current research on the cell cultures of the Chinese hamster, says Pühler. A further project has already been agreed with the University of Natural Resources and Life Sciences in Vienna and the Austrian Center of Industrial Biotechnology. 'This places Bielefeld University in a good position to carry on contributing to this highly competitive field of research.'


Story Source:

The above story is based on materials provided by Universitaet Bielefeld. Note: Materials may be edited for content and length.


Journal Reference:

  1. Karina Brinkrolf, Oliver Rupp, Holger Laux, Florian Kollin, Wolfgang Ernst, Burkhard Linke, Rudolf Kofler, Sandrine Romand, Friedemann Hesse, Wolfgang E Budach, Sybille Galosy, Dethardt Müller, Thomas Noll, Johannes Wienberg, Thomas Jostock, Mark Leonard, Johannes Grillari, Andreas Tauch, Alexander Goesmann, Bernhard Helk, John E Mott, Alfred Pühler, Nicole Borth. Chinese hamster genome sequenced from sorted chromosomes. Nature Biotechnology, 2013; 31 (8): 694 DOI: 10.1038/nbt.2645

Cite This Page:

Universitaet Bielefeld. "Hamster genome decoded: Researchers successfully sequence genome of Chinese hamster." ScienceDaily. ScienceDaily, 21 August 2013. <www.sciencedaily.com/releases/2013/08/130821094823.htm>.
Universitaet Bielefeld. (2013, August 21). Hamster genome decoded: Researchers successfully sequence genome of Chinese hamster. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/08/130821094823.htm
Universitaet Bielefeld. "Hamster genome decoded: Researchers successfully sequence genome of Chinese hamster." ScienceDaily. www.sciencedaily.com/releases/2013/08/130821094823.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) — Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) — Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) — He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) — An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins