Featured Research

from universities, journals, and other organizations

Why are some cells more cancer prone?

Date:
August 27, 2013
Source:
Carnegie Institution
Summary:
Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely.

Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely.

New work from Carnegie's Alexis Marianes and Allan Spradling used some of the most experimentally accessible tissue stem cells, the adult stem cells in the midsection of the fruit fly gut, with surprising results. Their findings are published by eLife.

Like the small intestine in mammals, the midgut of fruit flies is where most digestion takes place. Scientists had noticed a few regions in both the midgut and small intestine were specialized for certain tasks, such as absorbing iron, but had little understanding of the extent of these regional differences or how they were maintained.

Marianes and Spradling were able to demonstrate that there are 10 different major subregions within the fruit fly midgut. They occur in a specific order and each is responsible for different digestive and nutrient-storage processes, as evidenced by the expression of many specific genes. Most importantly, the adult stem cells in each region are specialized as well, and only support the types of cells found within it. Thus, during development, achieving the right spatial sequence of stem cells is probably critical to causing intestines to be built and maintained in order to function optimally.

The researchers also showed that tumors arise preferentially in specific regions of the midgut, a phenomenon well known in oncology. They showed the tumor-prone regions were specialized for lipid absorption, and stem cell function in them differed in small ways from stem cell function in other regions.

This work will motivate the search for fine-grained specialization in both tissue organization and in stem cells within many mammalian tissues. These subtle differences may explain the surprising results that are sometimes obtained following the removal or transplantation of human tissue. This must be considered carefully in ongoing attempts to utilize stem cells therapeutically.

Finally, it may be possible to learn what makes some stem cells more susceptible to cancer than others, and develop strategies to counteract this tendency.

Article: http://elife.elifesciences.org/content/2/e00886


Story Source:

The above story is based on materials provided by Carnegie Institution. Note: Materials may be edited for content and length.


Cite This Page:

Carnegie Institution. "Why are some cells more cancer prone?." ScienceDaily. ScienceDaily, 27 August 2013. <www.sciencedaily.com/releases/2013/08/130827160516.htm>.
Carnegie Institution. (2013, August 27). Why are some cells more cancer prone?. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2013/08/130827160516.htm
Carnegie Institution. "Why are some cells more cancer prone?." ScienceDaily. www.sciencedaily.com/releases/2013/08/130827160516.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins