Featured Research

from universities, journals, and other organizations

Microelectronics: Automating cancer detection

Date:
August 31, 2013
Source:
The Agency for Science, Technology and Research (A*STAR)
Summary:
Microelectronic engineers have developed and tested sensor technology that can detect and measure a chemical signature of bladder cancer. The light-based sensor could eventually be used for the early diagnosis and subsequent tracking of the progression and treatment of many different tumors, according to researchers.

Microelectronic engineers in Singapore have developed and tested sensor technology that can detect and measure a chemical signature of bladder cancer. The light-based sensor could eventually be used for the early diagnosis and subsequent tracking of the progression and treatment of many different tumors, according to Yong Shin at the A*STAR Institute of Microelectronics, who led the research. After further testing of the technology, Shin and co-workers are planning to develop a lab-on-a-chip device incorporating the sensor that can process fluid samples within about five minutes.

Genes that suppress tumors can be deactivated by the attachment of a methyl group to a specific DNA sequence -- cytosine next to guanine -- in their promoter region. The methyl group prevents the gene from being used as a template for protein synthesis and reduces the capacity of the cell to control its own proliferation.

Several well-established chemical methods exist for detecting such DNA methylation, but they are expensive, time-consuming and dependent on laboratory expertise. Shin and co-workers therefore investigated direct physical methods as an alternative. They focused particularly on silicon micro-ring resonators that amplify light at specific resonant frequencies. The resonators developed by the researchers are very sensitive detectors of a shift in light frequency, including the shift that occurs when a methyl group is attached or detached to DNA.

Shin and co-workers tested the capacity of silicon micro-ring resonators to discriminate between methylated and unmethylated forms of genes known to trigger cancer in bladder cells. They fashioned separate DNA probes to capture one or other form when they passed a solution of the genes, amplified by the polymerase chain reaction, over a silicon chip to which the probes were attached. The resonators clearly distinguished between the forms within five minutes. Moreover, the method allowed the team to quantify the density of methylation, which means the technique should be able to track changes in patterns of methylation.

"Our sensors could be widely useful for DNA methylation detection specifically and rapidly in the field," says Shin.

He also notes that the team has published several research papers on using silicon micro-ring resonators. "Among the techniques we have published is a novel technique that can be integrated with the methylation-specific sensor to amplify the methylated DNA from low amounts of DNA," he explains. "So, we are now trying to make a single microfluidic-based chip system that integrates several techniques, such as DNA extraction, conversion, amplification and detection."


Story Source:

The above story is based on materials provided by The Agency for Science, Technology and Research (A*STAR). Note: Materials may be edited for content and length.


Journal Reference:

  1. Yong Shin, Agampodi Promoda Perera, Jack Sheng Kee, Junfeng Song, Qing Fang, Guo-Qiang Lo, Mi Kyoung Park. Label-free methylation specific sensor based on silicon microring resonators for detection and quantification of DNA methylation biomarkers in bladder cancer. Sensors and Actuators B: Chemical, 2013; 177: 404 DOI: 10.1016/j.snb.2012.11.058

Cite This Page:

The Agency for Science, Technology and Research (A*STAR). "Microelectronics: Automating cancer detection." ScienceDaily. ScienceDaily, 31 August 2013. <www.sciencedaily.com/releases/2013/08/130831110649.htm>.
The Agency for Science, Technology and Research (A*STAR). (2013, August 31). Microelectronics: Automating cancer detection. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/08/130831110649.htm
The Agency for Science, Technology and Research (A*STAR). "Microelectronics: Automating cancer detection." ScienceDaily. www.sciencedaily.com/releases/2013/08/130831110649.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins