Featured Research

from universities, journals, and other organizations

Unreliable commercial lab kits may be hindering fight against cancer

Date:
October 4, 2013
Source:
American Association for Clinical Chemistry (AACC)
Summary:
A new study shows for the first time that low quality commercial lab kits may be one factor hampering the progress of cancer diagnostics.

Over the past 30 years, researchers have developed surprisingly few new tests for diagnosing cancer in spite of impressive advances in biomedical technology. A study appearing online today in Clinical Chemistry, the journal of AACC, shows for the first time that low quality commercial lab kits may be one factor hampering the progress of cancer diagnostics.

A doctor's ability to test for cancer in its earlier stages often determines a patient's chances of survival. Pancreatic ductal adenocarcinoma (PDAC) is a grim example of this. The majority of patients live only 3 to 18 months, because current diagnosis methods usually can't detect PDAC until it is too advanced to respond to treatment. Testing for the right biomarkers -- biological molecules whose presence indicates a condition or disease -- could be instrumental in the early detection of cancers like PDAC.

A team of researchers led by Eleftherios P. Diamandis, MD, PhD, of the University of Toronto, were hopeful they had found a new pancreatic cancer biomarker, the protein CUZD1, when they realized a faulty immunoassay kit had produced the data supporting CUZD1's viability. Using a kit marketed for CUZD1 detection, the team had successfully differentiated between pancreatic cancer and benign patient samples. Further analysis, however, revealed that the kit performed well because it actually detected the established tumor marker CA125. CUZD1 and CA125 share no molecular similarities that explain this error. This means that lax quality control during the manufacturing of the kit most likely caused this mix up.

Most investigators rely on commercial lab kits to evaluate the potential of candidate biomarkers. This study demonstrates, though, that costly risks counter the ease of using such kits. Diamandis's team lost 2 years, approximately $500,000, and thousands of valuable patient specimens, while also inadvertently raising false expectations about a potential breakthrough in PDAC testing because of the error in this lab kit.

"Reports like this one are relatively rare in the literature, since negative results are not usually published," said Diamandis. "However, these findings can contribute significantly to improving the quality of products intended for research purposes, and can save considerable research time and resources which would otherwise be wasted."

In this paper, the authors propose experiments to confirm the reliability of commercial lab kits. They hope this will help other researchers avoid similar problems, while also speeding up the development of much-needed effective cancer tests.

A podcast on this paper is available here: media.aacc.org/CCJPodcasts/ClinChem_201402_Prassas.mp3" href="http://media.aacc.org/CCJPodcasts/ClinChem_201402_Prassas.mp3">http://media.aacc.org/CCJPodcasts/ClinChem_201402_Prassas.mp3


Story Source:

The above story is based on materials provided by American Association for Clinical Chemistry (AACC). Note: Materials may be edited for content and length.


Journal Reference:

  1. I. Prassas, D. Brinc, S. Farkona, F. Leung, A. Dimitromanolakis, C. C. Chrystoja, R. Brand, V. Kulasingam, I. M. Blasutig, E. P. Diamandis. False Biomarker Discovery Due to Reactivity of a Commercial ELISA for CUZD1 with Cancer Antigen CA125. Clinical Chemistry, 2013; DOI: 10.1373/clinchem.2013.215236

Cite This Page:

American Association for Clinical Chemistry (AACC). "Unreliable commercial lab kits may be hindering fight against cancer." ScienceDaily. ScienceDaily, 4 October 2013. <www.sciencedaily.com/releases/2013/10/131004124935.htm>.
American Association for Clinical Chemistry (AACC). (2013, October 4). Unreliable commercial lab kits may be hindering fight against cancer. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/10/131004124935.htm
American Association for Clinical Chemistry (AACC). "Unreliable commercial lab kits may be hindering fight against cancer." ScienceDaily. www.sciencedaily.com/releases/2013/10/131004124935.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins