Featured Research

from universities, journals, and other organizations

New 'click' reaction: Chemistry applicable to living organisms

Date:
October 16, 2013
Source:
Commissariat a l'Energie Atomique (CEA)
Summary:
Chemists have developed a new “click” chemistry process for specific assembly of two components without modifying their properties or the medium in which the reaction takes place. The process can be carried out under any conditions, whatever the characteristics of the medium. This new click reaction can be used to connect two components (molecules, proteins, nanoparticles, etc.) in biological media as complex as human blood.

Illustration. Chemists have developed a new “click” chemistry process for specific assembly of two components without modifying their properties or the medium in which the reaction takes place.
Credit: Image courtesy of Commissariat a l'Energie Atomique (CEA)

Two CEA-Ibitec-S teams have developed a new "click" chemistry process for specific assembly of two components without modifying their properties or the medium in which the reaction takes place. The process can be carried out under any conditions, whatever the characteristics of the medium. This new click reaction can be used to connect two components (molecules, proteins, nanoparticles, etc.) in biological media as complex as human blood.

Related Articles


These results have been published on the Angewandte Chemie website.

Using an approach based on high-speed screening of thousands of reagent combinations, two Ibitec-S teams have discovered a new reaction meeting all the criteria of what is known as click chemistry:

  • effective under any reaction conditions;
  • applicable to biological media;
  • selective (the reaction must not interfere with satisfactory functioning of the medium).

The reaction developed by the researchers can assemble two components specifically, without altering their properties or their medium. This is accomplished by attaching a particular chemical group to each of the components (two proteins, for example): a dipole called sydnone (heterocyclic chemical group bearing a positive and a negative charge) to one component, an alkyne group (with a triple chemical bond) to the other. These two groups act to "click" the two components together when the click reaction catalyst (copper) is injected into the medium.

Applications

Although chemists have thousands of chemical reactions they can use to build increasingly sophisticated molecular edifices, only a few of these reactions can be used by biologists. Biological media have characteristics (temperature, water, osmotic pressure, etc.) that make it impossible to transpose most chemical reactions to them, even reactions that are fully mastered in vitro. The requirements for a reaction applicable to biological media are particularly restrictive: aqueous medium, ambient temperature, presence of many functional groups (thiols, amines, etc.). Consequently, very few reactions can be used with biological materials.

This reaction can be used to connect two components in biological media as complex as human blood. The potential applications of this new click reaction extend from medicinal chemistry (e.g. attachment of drugs to therapeutic antibodies) to biotechnology (e.g. tracers for medical imaging).


Story Source:

The above story is based on materials provided by Commissariat a l'Energie Atomique (CEA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Sergii Kolodych, Evelia Rasolofonjatovo, Manon Chaumontet, Marie-Claire Nevers, Christophe Crιminon, Frιdιric Taran. Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening. Angewandte Chemie International Edition, 2013; DOI: 10.1002/anie.201305645

Cite This Page:

Commissariat a l'Energie Atomique (CEA). "New 'click' reaction: Chemistry applicable to living organisms." ScienceDaily. ScienceDaily, 16 October 2013. <www.sciencedaily.com/releases/2013/10/131016100106.htm>.
Commissariat a l'Energie Atomique (CEA). (2013, October 16). New 'click' reaction: Chemistry applicable to living organisms. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/10/131016100106.htm
Commissariat a l'Energie Atomique (CEA). "New 'click' reaction: Chemistry applicable to living organisms." ScienceDaily. www.sciencedaily.com/releases/2013/10/131016100106.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

NASA's First 3-D Printer In Space Creates Its First Object

NASA's First 3-D Printer In Space Creates Its First Object

Newsy (Nov. 26, 2014) — The International Space Station is now using a proof-of-concept 3D printer to test additive printing in a weightless, isolated environment. Video provided by Newsy
Powered by NewsLook.com
Bolivian Recycling Initiative Turns Plastic Waste Into School Furniture

Bolivian Recycling Initiative Turns Plastic Waste Into School Furniture

Reuters - Innovations Video Online (Nov. 26, 2014) — Innovative recycling project in La Paz separates city waste and converts plastic garbage into school furniture made from 'plastiwood'. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Blu-Ray Discs Getting Second Run As Solar Panels

Blu-Ray Discs Getting Second Run As Solar Panels

Newsy (Nov. 26, 2014) — Researchers at Northwestern University are repurposing Blu-ray movies for better solar panel technology thanks to the discs' internal structures. Video provided by Newsy
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins