Featured Research

from universities, journals, and other organizations

Global HIV vaccine shows promise in monkeys

Date:
October 24, 2013
Source:
Beth Israel Deaconess Medical Center
Summary:
The considerable diversity of HIV worldwide represents a critical challenge for designing an effective HIV vaccine. Now a scientific team shows that mosaic antigens might overcome this challenge.

The considerable diversity of HIV worldwide represents a critical challenge for designing an effective HIV vaccine. Now, a scientific team led by Beth Israel Deaconess Medical Center (BIDMC) has shown that bioinformatically optimized HIV vaccine antigens known as "mosaic" antigens might be useful in the design of a global HIV vaccine. This study, which was conducted in monkeys, is published today in the journal Cell.

"A global HIV vaccine would offer major biomedical and practical advantages over most other HIV vaccine candidates, which are limited to certain regions of the world," says lead author Dan H. Barouch, MD, PhD, Director of the Center for Virology and Vaccine Research at BIDMC, Director of the Vaccine Program at the Ragon Institute of MGH, MIT and Harvard, and Professor of Medicine at Harvard Medical School. "To our knowledge, this study represents the first evaluation of the protective efficacy of a candidate global HIV antigen strategy in nonhuman primates."

In this new publication, the authors demonstrate for the first time that mosaic HIV vaccine antigens can afford partial protection in rhesus monkeys against challenges with a stringent simian-human immunodeficiency virus. These mosaic vaccine antigens have been developed for optimal immunologic coverage of global HIV diversity.

Barouch and his team studied the immunogenicity of HIV mosaic Env/Gag/Pol antigens administered to monkeys using viral vectors. Env, Gag, and Pol are three major HIV proteins. After immunization, the monkeys were repetitively exposed to multiple simian-human immunodeficiency virus challenges and the investigators evaluated the ability of the vaccines to block infection.

Although most animals immunized with the mosaic HIV vaccine became infected by the end of the study, the researchers observed an 87 to 90 percent reduction in monkeys' probability of becoming infected each time they were exposed to the virus. In contrast, monkeys that received sham vaccines became infected more quickly.

"These findings indicate that these optimized vaccine antigens can afford partial protection in a stringent animal model," says Barouch.

The investigators found that the immunized monkeys mounted antibody responses against diverse strains of HIV noting, "Protection was dependent on several different types of antibody responses, suggesting that the coordinated activity of multiple antibody functions may contribute to protection against difficult-to-neutralize viruses." The monkeys also mounted cellular immune responses to multiple regions of the virus.

The researchers note that most previous HIV vaccine candidates have typically only been tested in monkeys for protection against easy-to-neutralize viruses rather than against a difficult-to-neutralize virus like the one used in this study. Also, each viral challenge in the study was approximately 100-fold more infectious than typical sexual HIV exposures in humans.

"These data suggest a path forward for the development of a global HIV vaccine and give us hope that such a vaccine might indeed be possible," said Barouch. "We are planning to advance this HIV vaccine candidate into clinical trials next year," he adds.


Story Source:

The above story is based on materials provided by Beth Israel Deaconess Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dan Barouch et al. Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys. Cell, October 2013

Cite This Page:

Beth Israel Deaconess Medical Center. "Global HIV vaccine shows promise in monkeys." ScienceDaily. ScienceDaily, 24 October 2013. <www.sciencedaily.com/releases/2013/10/131024121150.htm>.
Beth Israel Deaconess Medical Center. (2013, October 24). Global HIV vaccine shows promise in monkeys. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2013/10/131024121150.htm
Beth Israel Deaconess Medical Center. "Global HIV vaccine shows promise in monkeys." ScienceDaily. www.sciencedaily.com/releases/2013/10/131024121150.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins