Featured Research

from universities, journals, and other organizations

Attractants prevent nerve cell migration

Date:
November 21, 2013
Source:
University of Bonn
Summary:
A vision is to implant nerve precursor cells in patients with Parkinson's and Huntington's diseases. However, the implanted nerve cells frequently do not migrate as hoped. Scientists have now discovered an important cause of this: Attractants secreted by the precursor cells prevent the maturing nerve cells from migrating into the brain.

A vision is to implant nerve precursor cells in the diseased brains of patients with Parkinson's and Huntington's diseases, whereby these cells are to assume the function of the cells that have died off. However, the implanted nerve cells frequently do not migrate as hoped, rather they hardly move from the site. Scientists at the Institute for Reconstructive Neurobiology at Bonn University have now discovered an important cause of this: Attractants secreted by the precursor cells prevent the maturing nerve cells from migrating into the brain. The results are presented in the journal Nature Neuroscience.

Related Articles


One approach for treating patients with Parkinson's or Huntington's disease is to replace defective brain cells with fresh cells. To do this, immature precursor cells from neurons are implanted into the diseased brains; these cells are to then mature on-site and take over the function of the defective cells. "However, it has been shown again and again that the nerve cells generated by the transplant barely migrate into the brain but remain largely confined to the implant site," says Prof. Dr. Oliver Brüstle, Director of the Institute for Reconstructive Neurobiology at Bonn University. Scientists have believed for a long time that this effect is associated with the fact that in the mature brain, there are unfavorable conditions for the uptake of additional nerve cells.

Immature and more mature nerve cells attract each other like magnets

The researchers from the Institute for Reconstructive Neurobiology of Bonn University have now discovered a fully unexpected mechanism to which the deficient migratory behavior of the graft-derived neurons can be attributed. The implanted cells mature at different rates and thus there is a mixture of the two stages. "Like magnets, the precursor cells which are still largely immature attract the nerve cells which have already matured further, which is why there is a sort of agglomeration," says lead author Dr. Julia Ladewig, who was recently awarded a research prize of 1.25 million Euro by the North Rhine-Westphalian Stem Cell Network, which is supported by State Ministry of Science and Research.

The cause of the attractive force which has remained hidden to date involves chemical attractants which are secreted by the precursor cells. "In this way, the nerve precursor cells prevent the mature brain cells from penetrating further into the tissue," says Dr. Philipp Koch, who performed the primary work for the study as an additional lead author, together with Dr. Ladewig.

The scientists had initially observed that, the more precursor cells contained in the transplant, the worse the migration of nerve cells is. In a second step, the researchers from the Institute for Reconstructive Neurobiology at Bonn University were able to decode and inactivate the attractants responsible for the agglomeration of mature and immature neurons. When the scientists deactivated the receptor tyrosine kinase ligands FGF2 and VEGF with inhibitors, mature nerve cells migrated better into the animal brains and dispersed over much larger areas.

Promising universal approach for transplants

"This is a promising new approach to solve an old problem in neurotransplantation," Prof. Brüstle summarizes. Through the inhibition of attractants, the migration of implanted nerve precursor cells into the brain can be significantly improved. As the researchers have shown in various models with precursor cells from animals and humans, the mechanism is a fundamental principle which also functions across species. "However, more research is still needed to transfer the principle into clinical application," says Prof. Brüstle.


Story Source:

The above story is based on materials provided by University of Bonn. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julia Ladewig, Philipp Koch, Oliver Brüstle. Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration. Nature Neuroscience, 2013; DOI: 10.1038/nn.3583

Cite This Page:

University of Bonn. "Attractants prevent nerve cell migration." ScienceDaily. ScienceDaily, 21 November 2013. <www.sciencedaily.com/releases/2013/11/131121105150.htm>.
University of Bonn. (2013, November 21). Attractants prevent nerve cell migration. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2013/11/131121105150.htm
University of Bonn. "Attractants prevent nerve cell migration." ScienceDaily. www.sciencedaily.com/releases/2013/11/131121105150.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Whale-Watching Scientists Spot Baby Orca

Whale-Watching Scientists Spot Baby Orca

AP (Feb. 28, 2015) — Researchers following endangered killer whales spotted a baby orca off the coast of Washington state, the third birth documented this winter but still leaving the population dangerously low. (Feb. 28) Video provided by AP
Powered by NewsLook.com
The Best Drinks for Your Health

The Best Drinks for Your Health

Buzz60 (Feb. 27, 2015) — When it comes to health and fitness, there&apos;s lots of talk about what foods to eat, but there are a few liquids that can promote good nutrition. Krystin Goodwin (@krystingoodwin) has the healthiest drinks to boost your health! Video provided by Buzz60
Powered by NewsLook.com
Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) — From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) — If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins