Featured Research

from universities, journals, and other organizations

New agent against cancer cells

Date:
November 26, 2013
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Scientists have discovered a new active substance that inhibits cell division in leukemia cells and could play an important role in the fight against cancer.

In the case of leukemia, genetic mutations can cause a disturbance in signaling transduction: The cells continue to divide unchecked, causing damage to the entire organism.
Credit: Albert-Ludwigs-Universität Freiburg

Freiburg scientists have discovered a substance that suppresses unchecked cell division in leukemia cells Scientists of the University of Freiburg and the Freiburg University Medical Center from the collaborative research center Medical Epigenetics (SFB 992) have discovered a new active substance that inhibits cell division in leukemia cells and could play an important role in the fight against cancer.

Related Articles


Junior professor Dr. Stefan Günther was in charge of the research project, which also included research groups participating in SFB 992 Medical Epigenetics led by Prof. Dr. Manfred Jung from the Institute of Pharmaceutical Sciences, Prof. Dr. Oliver Einsle from the Institute of Biochemistry, and Prof. Dr. Roland Schüle from the Freiburg University Medical Center. The team published their findings in the journal Angewandte Chemie International Edition.

The substance XD14 suppresses the function of several proteins from the BET family also known as epigenetic reader proteins: They identify epigenetic changes in so-called histones and pass on this signal, for instance in order to trigger cell division. In the case of leukemia, genetic mutations can cause a disturbance in signaling transduction: The cells continue to divide unchecked, causing damage to the entire organism.

The scientists detected the new agent with a method called virtual screening: The Pharmaceutical Bioinformatics Research Group, headed by Stefan Günther, studied the characteristics of roughly ten million molecules in a computer model. The goal was to identify the few substances whose binding affinity is so great that they can prevent certain proteins of the BET family from passing on signals. The complex calculations involved in this endeavor were made in a computer network maintained by the universities of Baden-Württemberg, the bwGRID. The scientists tested one of the substances on 60 different types of cancer cells. The experiment proved that the agent can significantly suppress cell division in leukemia cells. They are now investigating whether the molecule is suitable for use as a drug.

Around 20 different research groups from the University of Freiburg, the Freiburg University Medical Center, and the Max Planck Institute of Immunobiology and Epigenetics are collaborating on the study of epigenetic mechanisms in SFB 992 in order to develop new strategies for fighting diseases. The DNA stores information on genetic features and passes them on by means of cell division. Epigenetic features, on the other hand, are passed on without being part of the genetic code.


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xavier Lucas, Daniel Wohlwend, Martin Hügle, Karin Schmidtkunz, Stefan Gerhardt, Roland Schüle, Manfred Jung, Oliver Einsle, Stefan Günther. 4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading. Angewandte Chemie International Edition, 2013; DOI: 10.1002/anie.201307652

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "New agent against cancer cells." ScienceDaily. ScienceDaily, 26 November 2013. <www.sciencedaily.com/releases/2013/11/131126092445.htm>.
Albert-Ludwigs-Universität Freiburg. (2013, November 26). New agent against cancer cells. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/11/131126092445.htm
Albert-Ludwigs-Universität Freiburg. "New agent against cancer cells." ScienceDaily. www.sciencedaily.com/releases/2013/11/131126092445.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) — Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) — A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins