Featured Research

from universities, journals, and other organizations

Aging cells unravel their DNA

Date:
December 16, 2013
Source:
Rockefeller University Press
Summary:
The study identifies a common, early marker of senescent cells that could have important implications for tumor suppression and aging-related diseases like Progeria.

Satellite DNA (green) is compact in a normal proliferative cell (left) but distended in a nonproliferative senescent cell (right). A study in The Journal of Cell Biology identifies a common marker of senescence that could have important implications for aging and cancer.
Credit: Swanson et al., 2013

Senescent cells, which are metabolically active but no longer capable of dividing, contribute to aging, and senescence is a key mechanism for preventing the spread of cancer cells. A study in The Journal of Cell Biology identifies a common, early marker of senescent cells that could have important implications for tumor suppression and aging-related diseases like Progeria.

Senescent cells permanently exit the cell cycle, a process that can be triggered by the cellular changes associated with aging or by other stresses such as the expression of cancer-promoting oncogenes. Despite the importance of senescence for both aging and tumor suppression, however, researchers have failed to identify any distinguishing features that are common to all types of senescent cells.

Researchers from UMass Medical School discovered that the satellite DNA found at human and mouse centromeres -- the points where chromosomes connect to microtubules during cell division -- unraveled from its normal compact state as cells entered senescence. This unraveling -- which the researchers termed senescence-associated distension of satellites, or SADS -- occurred regardless of how senescence was induced and appeared to occur early in the process of cell cycle exit. Strikingly, cells from Progeria patients formed SADS as they exited the cell cycle, suggesting that these prematurely arrested cells follow the same senescence pathway as normally aging cells.

The extensive unfolding of structures critical for cell division could thus prove key to inhibiting cell proliferation, in the context of both aging and limiting the proliferation of tumor cells.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. C. Swanson, B. Manning, H. Zhang, J. B. Lawrence. Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence. The Journal of Cell Biology, 2013; DOI: 10.1083/jcb.201306073

Cite This Page:

Rockefeller University Press. "Aging cells unravel their DNA." ScienceDaily. ScienceDaily, 16 December 2013. <www.sciencedaily.com/releases/2013/12/131216142004.htm>.
Rockefeller University Press. (2013, December 16). Aging cells unravel their DNA. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/12/131216142004.htm
Rockefeller University Press. "Aging cells unravel their DNA." ScienceDaily. www.sciencedaily.com/releases/2013/12/131216142004.htm (accessed September 22, 2014).

Share This



More Plants & Animals News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cat Lovers Flock to Los Angeles

Cat Lovers Flock to Los Angeles

AFP (Sep. 22, 2014) The best funny internet cat videos are honoured at LA's Feline Film Festival. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Top 3 Outrageous Animal Stories Of The Week

Top 3 Outrageous Animal Stories Of The Week

Newsy (Sep. 19, 2014) This week's animal stories include a goldfish having surgery, a pizza chain giving out pets, and a tiger found on the side of the road. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins