Featured Research

from universities, journals, and other organizations

Simple test can indicate cervical cancer

Date:
January 9, 2014
Source:
University of Louisville
Summary:
Researchers have confirmed that using the heat profile from a person’s blood, called a plasma thermogram, can serve as an indicator for the presence or absence of cervical cancer, including the stage of cancer.

Researchers at the University of Louisville have confirmed that using the heat profile from a person's blood, called a plasma thermogram, can serve as an indicator for the presence or absence of cervical cancer, including the stage of cancer.

The team, led by Nichola Garbett, Ph.D., published its findings online today in PLOS ONE.

"We have been able to demonstrate a more convenient, less intrusive test for detecting and staging cervical cancer," Garbett said. "Additionally, other research has shown that we are able to demonstrate if the current treatment is effective so that clinicians will be able to better tailor care for each patient."

To generate a plasma thermogram, a blood plasma sample is "melted" producing a unique signature indicating a person's health status. This signature represents the major proteins in blood plasma, measured by Differential Scanning Calorimetry (DSC). The team, which includes Brad Chaires, Ph.D., Ben Jenson, Ph.D., William Helm, M.D., Michael Merchant, Ph.D., and Jon Klein, M.D., Ph.D., from the University of Louisville School of Medicine, have demonstrated that the plasma thermogram profile varies when a person has or does not have the disease. The team believes that molecules associated with the presence of disease, called biomarkers, can affect the thermogram of someone with cervical disease. They used mass spectrometry to show that biomarkers associated with cervical cancer existed in the plasma.

"The key is not the actual melting temperature of the thermogram, but the shape of the heat profile," Garbett said. "We have been able to establish thermograms for a number of diseases. Comparing blood samples of patients who are being screened or treated against those thermograms should enable us to better monitor patients as they are undergoing treatment and follow-up. This will be a chance for us to adjust treatments so they are more effective."

Chaires noted that plasma thermograms have different patterns associated with different demographics, as well as for different diseases. This results in a more thorough application of the test as a person's thermogram can be compared to specific demographic reference profiles or, even better, to the person's own profile. Using a person's unique thermogram would provide the most accurate application of the test which could be used as part of a personalized medicine approach.

Further clinical study could result in the plasma thermogram as a compliment test to the traditional screening method for cervical cancer, the Pap smear and would be less intrusive and more convenient for the patient. Additionally, because the plasma thermogram test could allow treatment effectiveness to be more easily monitored, treatment that was not working could be stopped sooner and replaced with more effective treatment. In summary, the test could result in earlier detection, more effective therapeutic approaches and lowered healthcare costs for screening and treatment of cervical cancer.

The University of Louisville researchers see great promise for their technique being able to detect and monitor in a range of other cancers and diseases. The test is non-invasive and requires only a simple blood draw. The plasma thermogram test has already been applied to identify multiple cancers, including melanoma, lung, cervical, ovarian, endometrial and uterine cancers and other diseases, including lupus, rheumatoid arthritis, Amyotrophic lateral sclerosis (Lou Gehrig's Disease) and Lyme disease. The test has shown great promise as a prognostic indicator of disease, allowing physicians to monitor cancer patients more closely for remission, response-to-therapy and recurrence.


Story Source:

The above story is based on materials provided by University of Louisville. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nichola C. Garbett, Michael L. Merchant, C. William Helm, Alfred B. Jenson, Jon B. Klein, Jonathan B. Chaires. Detection of Cervical Cancer Biomarker Patterns in Blood Plasma and Urine by Differential Scanning Calorimetry and Mass Spectrometry. PLoS ONE, 2014; 9 (1): e84710 DOI: 10.1371/journal.pone.0084710

Cite This Page:

University of Louisville. "Simple test can indicate cervical cancer." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109003804.htm>.
University of Louisville. (2014, January 9). Simple test can indicate cervical cancer. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2014/01/140109003804.htm
University of Louisville. "Simple test can indicate cervical cancer." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109003804.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins