Featured Research

from universities, journals, and other organizations

Multihormone reverses metabolic damage of high calorie diet

Date:
January 15, 2014
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
A single molecule, which acts equally on the receptors of the metabolic hormones glucagon and glucagon-like peptide-1 (GLP-1) improves body weight and diabetes through restored function of the anti-obesity hormone leptin. Importantly, scientists found that treatment of obese mice with this GLP-1/Glucagon co-agonist improves metabolism and body weight associated with restored function of the weight lowering hormone leptin, even in the continued presence of a high-fat, high-sugar diet.

A single molecule, which acts equally on the receptors of the metabolic hormones glucagon and glucagon-like peptide-1 (GLP-1) improves body weight and diabetes through restored function of the anti-obesity hormone leptin. This was discovered by an international team comprising scientists from the Helmholtz Center Munich, Germany, Indiana University and the San Diego-based biotech company Ambrx.

Importantly, the scientists found out that treatment of obese mice with this GLP-1/Glucagon co-agonist improves metabolism and body weight associated with restored function of the weight lowering hormone leptin, even in the continued presence of a high-fat, high-sugar diet. The results are published in the current issue of the official journal of the American Diabetes Association 'Diabetes'.

The adipocyte hormone leptin plays a key role in the physiology of energy and glucose metabolism. Leptin is normally secreted from adipose tissue to blood in proportion to the amount of body fat. Increased leptin levels inform the brain of stored calories and it responds to inhibit food intake, increase energy expenditure and decrease blood glucose. However, obese individuals are resistant to leptin's metabolic effects, which limits the use of leptin as an anti-obesity drug.

In their new study, the group of Dr. Timo Müller (Institute of Diabetes and Obesity, Helmholtz Center Munich, Germany) discovered that treatment of diet-induced obese mice with a peptide that simultaneously activates GLP-1/glucagon receptors reversed leptin resistance, improved body weight and normalized glucose metabolism even without switching to a healthier diet.

"We are particularly encouraged to see that adding leptin produced weight loss beyond the benefits of the peptide-based, co-agonist" says Prof. Matthias Tschöp, Research Director of the Helmholtz Diabetes Center and Chair of Metabolic Diseases at Technische Universität München, Germany.

The identification of this novel treatment strategy is the result of many years of collaboration with Ambrx and Prof. Richard DiMarchi (Indiana University) who noted: "The results are inspiring, and establish a basis for validation in human studies."

Dr. Christoffer Clemmensen, the lead author of the study, adds: "If this concept proves safe and efficient at least in specific subpopulations of obese patients, then we may have come a step closer to personalized prevention of type 2 diabetes."

Their findings, just published in the journal Diabetes, are aligned with the overall research objective of the Helmholtz Diabetes Center at Helmholtz Zentrum Munich, partner of the German Center for Diabetes Research (DZD). We aim to establish new approaches in the diagnosis, therapy and prevention of civilization's major diseases and to develop these approaches as quickly as possible in the context of translational research in order to provide specific benefits for society.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Küchler D, Sehrer L, Ograjsek T, Hofmann S, Schriever SS, Pfluger PT, Pinkstaff J, Tschöp MH, Dimarchi R, Müller TD. GLP-1/glucagon co-agonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes, December 2013

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Multihormone reverses metabolic damage of high calorie diet." ScienceDaily. ScienceDaily, 15 January 2014. <www.sciencedaily.com/releases/2014/01/140115075632.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2014, January 15). Multihormone reverses metabolic damage of high calorie diet. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2014/01/140115075632.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Multihormone reverses metabolic damage of high calorie diet." ScienceDaily. www.sciencedaily.com/releases/2014/01/140115075632.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) — The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) — A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) — The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) — The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins