Featured Research

from universities, journals, and other organizations

Study associates pro-inflammatory molecules with early death in HIV patients

Date:
January 16, 2014
Source:
Boston University Medical Center
Summary:
A study provides new insight into the impact that pro-inflammatory molecules have on early death in HIV patients who abuse alcohol. The findings pinpoint the inflammatory markers most associated with early death and may help explain why some patients die earlier than others even when all of these patients are on antiretroviral therapy.

A study led by researchers at Boston University School of Medicine (BUSM) provides new insight into the impact that pro-inflammatory molecules have on early death in HIV patients who abuse alcohol. The findings, published online in the journal AIDS, pinpoint the inflammatory markers most associated with early death and may help explain why some patients die earlier than others even when all of these patients are on antiretroviral therapy.

Daniel Fuster, MD, PhD, a researcher at the Clinical Addiction Research and Education (CARE) unit at BUSM, is the study's lead author. Unique in its investigation of inflammatory markers in HIV and alcohol abuse, the study is the product of collaboration between Boston University School of Public Health, Boston Medical Center and the University of Pittsburgh Graduate School of Public Health.

Although breakthroughs have been accomplished in HIV antiretroviral therapy, some patients fare better than others. Factors influencing these differences have been identified, including co-infection with hepatitis viruses (especially hepatitis C), substance abuse (alcohol, as well as other drugs), noncompliance with antiviral drugs, CD4+ cell count and HIV viral load. Additionally, researchers have previously identified pro-inflammatory molecules called cytokines that have been associated with elevated HIV viral loads and more advanced HIV disease. Independently, alcohol abuse and chronic hepatitis C infection have also been associated with higher levels of inflammation in the bodies of HIV infected persons. However, it was previously unknown if the elevated inflammatory state in these patients was due to their HIV or other independent risk factors.

Investigators recruited 400 HIV positive subjects who were known to abuse alcohol chronically. Half of these subjects also had chronic hepatitis C. They were followed for a three- to five-year period during which clinical information and laboratory samples were collected. Levels of seven well-known pro-inflammatory cytokine molecules were measured at baseline. From the beginning of the study in 2001 until data gathering was concluded in 2009, all patients were tracked in a national database to verify their survival status.

Based on this analysis, the researchers found that at the end of the study period, 85 out of the original 400 patients had died. Although these patients represent a population already at high risk of mortality from many problems (smoking, drug abuse, homelessness, etc.), most deaths in the study period were a result of either HIV or hepatitis C. Adjusting for known risk factors, such as age, smoking and hepatitis status, the researchers found that an increased burden of inflammation was strongly associated with increased mortality in alcohol-abusing HIV patients. This association was found, regardless of whether or not patients were taking their antiretroviral drugs. One inflammatory molecule in particular, known as interleukin-6 (IL-6) was found to have the strongest association with mortality among patients in the study.

"Current antiretroviral drug regimens may be able to improve mortality in most patients, but are unable to decrease the potentially dangerous burden of a chronic inflammatory state in the body," said Fuster. "Additional research should explore how to better manage chronic inflammation in these patients."


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniel Fuster, Debbie M. Cheng, Emily K. Quinn, Kaku A. Armah, Richard Saitz, Matthew S. Freiberg, Jeffrey H. Samet, Judith I. Tsui. Inflammatory cytokines and mortality in a cohort of HIV-infected adults with alcohol problems. AIDS, 2014; 1 DOI: 10.1097/QAD.0000000000000184

Cite This Page:

Boston University Medical Center. "Study associates pro-inflammatory molecules with early death in HIV patients." ScienceDaily. ScienceDaily, 16 January 2014. <www.sciencedaily.com/releases/2014/01/140116150814.htm>.
Boston University Medical Center. (2014, January 16). Study associates pro-inflammatory molecules with early death in HIV patients. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2014/01/140116150814.htm
Boston University Medical Center. "Study associates pro-inflammatory molecules with early death in HIV patients." ScienceDaily. www.sciencedaily.com/releases/2014/01/140116150814.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins