Featured Research

from universities, journals, and other organizations

Daily rhythms of our genes are disrupted when sleep times shift

Date:
January 20, 2014
Source:
University of Surrey
Summary:
A new study found that the daily rhythms of our genes are disrupted when sleep times shift.

Young man asleep. A new study has found that the daily rhythms of our genes are disrupted when sleep times shift.
Credit: © Photographee.eu / Fotolia

A new study from the University of Surrey, published today in the journal PNAS (Proceedings of the National Academy of Sciences), found that the daily rhythms of our genes are disrupted when sleep times shift.

Related Articles


Researchers placed twenty-two participants on a 28-hour day in a controlled environment without a natural light-dark cycle. As a result, their sleep-wake cycle was delayed by four hours each day, until sleep occurred 12 hours out of sync with their brain clock and in the middle of what would have been their normal 'daytime'. The team then collected blood samples to measure the participants' rhythms of gene expression.

During this disruption of sleep timing, there was a six-fold reduction in the number of genes that displayed a circadian rhythm (a rhythm with an approximately 24 hour period). This included many regulators associated with transcription and translation, indicating widespread disruption to many biological processes.

The study also revealed which genes may be regulated by sleep-wake cycles and which are regulated by central body clocks. This finding provides new clues about sleep's function as separate from the circadian clock.

Senior author Professor Derk-Jan Dijk, from the Sleep Research Centre at the University of Surrey said: "This research may help us to understand the negative health outcomes associated with shift work, jet lag and other conditions in which the rhythms of our genes are disrupted.

"The results also imply that sleep-wake schedules can be used to influence rhythmicity in many biological processes, which may be very relevant for conditions in which our body clocks are altered, such as in ageing."

Co-author, Dr Simon Archer, from the School of Biosciences and Medicine at the University of Surrey, added: "Over 97% of rhythmic genes become out of sync with mistimed sleep and this really explains why we feel so bad during jet lag, or if we have to work irregular shifts."


Story Source:

The above story is based on materials provided by University of Surrey. Note: Materials may be edited for content and length.


Journal Reference:

  1. Simon N. Archer, Emma E. Laing, Carla S. Mφller-Levet, Daan R. van der Veen, Giselda Bucca, Alpar S. Lazar, Nayantara Santhi, Ana Slak, Renata Kabiljo, Malcolm von Schantz, Colin P. Smith, and Derk-Jan Dijk. Mistimed sleep disrupts circadian regulation of the human transcriptome. Proceedings of the National Academy of Sciences, January 2014 DOI: 10.1073/pnas.1316335111

Cite This Page:

University of Surrey. "Daily rhythms of our genes are disrupted when sleep times shift." ScienceDaily. ScienceDaily, 20 January 2014. <www.sciencedaily.com/releases/2014/01/140120173334.htm>.
University of Surrey. (2014, January 20). Daily rhythms of our genes are disrupted when sleep times shift. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2014/01/140120173334.htm
University of Surrey. "Daily rhythms of our genes are disrupted when sleep times shift." ScienceDaily. www.sciencedaily.com/releases/2014/01/140120173334.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) — As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) — According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins