Featured Research

from universities, journals, and other organizations

Punctured cell membranes lead to high blood pressure

Date:
January 27, 2014
Source:
University of Southern Denmark
Summary:
Researchers have identified how a mutated protein can lead to holes in a protein sitting in a cell's membrane. Such holes cause high blood pressure, and the discovery can now lead to new and better medication for high blood pressure.

Researchers from the University of Southern Denmark have identified how a mutated protein can lead to holes in a protein sitting in a cell's membrane. Such holes cause high blood pressure, and the discovery can now lead to new and better medication for high blood pressure.

High blood pressure can be caused by many things -- one of them being a specific mutated protein. Now the researchers at University of Southern Denmark have found out exactly what unfortunate events in the human organism are initiated by the mutated protein.

"This knowledge can now lead to new and better medicines for high blood pressure," says the lead author of a new scientific publication, PhD student Wojciech Kopec from the Center for Biomembrane Physics (MEMPHYS) at the University of Southern Denmark.

He explains that some years ago research colleagues from University of Aarhus found out that a particular mutated protein is associated with high blood pressure. But the exact mechanism at play could not be clarified until now.

Wojciech Kopec and his colleagues, Himanshu Khandelia and Bastien Loubet from Memphys and Hanne Poulsen from University of Aarhus, have now revealed the mechanism at play: The mutated protein leads to the formation of holes in a protein sitting in a cell's membrane, and so the cell can no longer control what is allowed into and out of the cell interior. The holes are made where the cell controls its content of salts. A normal, healthy cell has full control of how much salt (sodium ions) must be removed from within the cell so that it can maintain a perfect salt balance in the organism, it is a part of.

"But when there are holes, sodium ions can penetrate into the cell, so the salt levels go up. Too high salt levels are associated with many diseases, including high blood pressure," explains Wojciech Kopec.

This specific knowledge is particularly useful for the medical industry involved with developing new drugs.

"Medicine is molecules, and therefore it is in principle easy to develop a molecular formula that can close the holes in the membrane," says Wojciech Kopec.


Story Source:

The above story is based on materials provided by University of Southern Denmark. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wojciech Kopec, Bastien Loubet, Hanne Poulsen, Himanshu Khandelia. Molecular Mechanism of Na ,K -ATPase Malfunction in Mutations Characteristic of Adrenal Hypertension. Biochemistry, 2014; 140124102203008 DOI: 10.1021/bi401425g

Cite This Page:

University of Southern Denmark. "Punctured cell membranes lead to high blood pressure." ScienceDaily. ScienceDaily, 27 January 2014. <www.sciencedaily.com/releases/2014/01/140127101240.htm>.
University of Southern Denmark. (2014, January 27). Punctured cell membranes lead to high blood pressure. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140127101240.htm
University of Southern Denmark. "Punctured cell membranes lead to high blood pressure." ScienceDaily. www.sciencedaily.com/releases/2014/01/140127101240.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins