Featured Research

from universities, journals, and other organizations

A simple new way to induce pluripotency: Acid

Date:
January 29, 2014
Source:
Nature Publishing Group
Summary:
An unusual reprogramming phenomenon by which the fate of somatic cells can be drastically altered through changes to the external environment is described in two new articles.

STAP cells generated entire fetus body.
Credit: Copyright Haruko Obokata

An unusual reprogramming phenomenon by which the fate of somatic cells can be drastically altered through changes to the external environment is described in two papers in this week's Nature.*

Postnatal somatic cells committed to a specific lineage are shown to be converted into a pluripotent state (capable of differentiating into nearly all cell types) when exposed to an environmental stress, in this case short exposure to low pH. This reprogramming process does not need nuclear manipulation or the introduction of transcription factors -- thought to be necessary to induce pluripotency -- so the work may have important implications for regenerative medicine.

Reprogramming in response to environmental stress has been observed in plants, whereby mature cells can become immature cells capable of forming a whole new plant structure, including roots and stalks. Whether animal cells have a similar potential has been a challenging question, but one that Haruko Obokata and co-authors have addressed. They demonstrate that mammalian somatic cells can be reprogrammed when stressed by low-pH conditions, and call the phenomenon stimulus-triggered acquisition of pluripotency (STAP).

So-called STAP cells have some characteristics that resemble embryonic stem cells, but the STAP cells only have a limited capacity for self-renewal. In a second paper, Obokata and colleagues investigate the nature of STAP cells and suggest that they represent a unique state of pluripotency. The researchers also demonstrate that under pluripotent stem-cell culture conditions STAP cells can be transformed into robustly self-renewing stem cells, similar to embryonic stem cells.

Together, these findings reveal that cells in the body have the potential to become pluripotent and provide new insights into the diverse cellular states.

*Editor's Note: Both articles were retracted by Nature on July 2, 2014.

See: http://www.nature.com/nature/journal/v511/n7507/full/nature13599.html

See: http://www.nature.com/nature/journal/v511/n7507/full/nature13598.html


Story Source:

The above story is based on materials provided by Nature Publishing Group. Note: Materials may be edited for content and length.


Journal References:

  1. Haruko Obokata, Teruhiko Wakayama, Yoshiki Sasai, Koji Kojima, Martin P. Vacanti, Hitoshi Niwa, Masayuki Yamato, Charles A. Vacanti. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 2014; 505 (7485): 641 DOI: 10.1038/nature12968
  2. Haruko Obokata, Yoshiki Sasai, Hitoshi Niwa, Mitsutaka Kadota, Munazah Andrabi, Nozomu Takata, Mikiko Tokoro, Yukari Terashita, Shigenobu Yonemura, Charles A. Vacanti, Teruhiko Wakayama. Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature, 2014; 505 (7485): 676 DOI: 10.1038/nature12969

Cite This Page:

Nature Publishing Group. "A simple new way to induce pluripotency: Acid." ScienceDaily. ScienceDaily, 29 January 2014. <www.sciencedaily.com/releases/2014/01/140129184445.htm>.
Nature Publishing Group. (2014, January 29). A simple new way to induce pluripotency: Acid. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140129184445.htm
Nature Publishing Group. "A simple new way to induce pluripotency: Acid." ScienceDaily. www.sciencedaily.com/releases/2014/01/140129184445.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins