Featured Research

from universities, journals, and other organizations

Mechanism of dengue virus entry into cells uncovered by research

Date:
February 17, 2014
Source:
Biophysical Society
Summary:
Despite its heavy toll, the prevention and clinical treatment of dengue infection has been a "dramatic failure in public health compared to other infectious diseases like HIV," said an author of a new article. Now, new research could offer vital insight into the mechanism of dengue virus entry into cells -- and aid vaccine and clinical drug development.

Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash. In some people the disease progresses to a severe, often fatal, form known as dengue hemorrhagic fever. Despite its heavy toll, the prevention and clinical treatment of dengue infection has been a "dramatic failure in public health compared to other infectious diseases like HIV," said Ping Liu of the University of North Carolina at Chapel Hill.

Now, new research by Liu and her colleagues, to be presented at the 58th Annual Biophysical Society Meeting, which takes place in San Francisco from Feb. 15-19, could offer vital insight into the mechanism of dengue virus entry into cells -- and aid vaccine and clinical drug development.

Specifically, Liu, a postdoctoral scholar in the laboratories of cell biologist Ken Jacobson and biophysical chemist Nancy Thompson, along with dengue fever expert Aravinda de Silva, used high-resolution microscopes to examine the expression of a particular protein, known as DC-SIGN (for dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin), on the surface of immune system cells called dendritic cells.

The normal role of DC-SIGN is to capture pathogens so that fragments of those pathogens can be presented as antigens on the surface of the dendritic cells. Such antigens then are recognized by T cells -- the workhorse cells of the immune system -- "which is one of the first steps in the normal immune response," Liu said.

While it has been known for some time that dengue used DC-SIGN to attach to cells, Liu and her colleagues used high-resolution microscopy to study exactly how the viruses used the protein to gain entry into cells. "DC-SIGN has a unique carbohydrate recognition domain on its extracellular portion, which binds to all sorts of carbohydrates on pathogens," she explained. (Other pathogens, including HIV and the bacterium that causes tuberculosis, are likely to use the same back door).

"An effective medication or vaccine should stop the process of dengue virus entry into cells," Liu said. To that end, she said, de Silva and his colleagues have identified strong neutralization antibodies that block dengue infection. "We are looking into the details of how those neutralization antibodies act and the role of DC-SIGN in the neutralization process." By identifying the mechanism of antibody neutralization, Liu and colleagues hope to advance the development of vaccines for Dengue virus infections.


Story Source:

The above story is based on materials provided by Biophysical Society. Note: Materials may be edited for content and length.


Cite This Page:

Biophysical Society. "Mechanism of dengue virus entry into cells uncovered by research." ScienceDaily. ScienceDaily, 17 February 2014. <www.sciencedaily.com/releases/2014/02/140217160941.htm>.
Biophysical Society. (2014, February 17). Mechanism of dengue virus entry into cells uncovered by research. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/02/140217160941.htm
Biophysical Society. "Mechanism of dengue virus entry into cells uncovered by research." ScienceDaily. www.sciencedaily.com/releases/2014/02/140217160941.htm (accessed October 22, 2014).

Share This



More Plants & Animals News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Reuters - US Online Video (Oct. 21, 2014) Police in Gary, Indiana are using cadaver dogs to search for more victims after a suspected serial killer confessed to killing at least seven women. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
White Lion Cubs Unveiled to the Public

White Lion Cubs Unveiled to the Public

Reuters - Light News Video Online (Oct. 21, 2014) Visitors to Belgrade zoo meet a pair of three-week-old lion cubs for the first time. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins