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Chemical chaperones have helped proteins do their jobs for billions of years

Date:
February 20, 2014
Source:
University of Michigan
Summary:
Proteins are the body's workhorses, and like horses they often work in teams. There exists a modern day team of multiple chaperone proteins that help other proteins fold into the complex 3D shapes they must achieve to function. This is necessary to avert many serious diseases caused when proteins misbehave. An ancient chemical, present for billions of years, appears to have helped proteins function properly since time immemorial.

Polyphosphate, colored yellow in this microscopic image, protects bacteria against protein-damaging stress conditions.
Credit: Image courtesy of University of Michigan

An ancient chemical, present for billions of years, appears to have helped proteins function properly since time immemorial. Proteins are the body's workhorses, and like horses they often work in teams. There exists a modern day team of multiple chaperone proteins that help other proteins fold into the complex 3D shapes they must achieve to function. This is necessary to avert many serious diseases caused when proteins misbehave.

But what happened before this team of chaperones was formed? How did the primordial cells that were the ancestors of modern life keep their proteins folded and functional?

Scientists from the University of Michigan discovered that an extremely simple, ancient chemical called polyphosphate can perform the role of a chaperone. It likely played that role billions of years ago, and still keeps its old job today.

"Polyphosphate has likely been present since life began on Earth, and is thought to exist in all living creatures," said postdoctoral researcher Michael Gray. "This means it's extremely important, but no one really knew what it was for.

"We found that bacteria accumulate polyphosphate to defend against disease-causing, protein unfolding conditions. Purified polyphosphate works well to protect proteins in the test tube, showing that this simple chemical can substitute for the complex team of protein chaperones."

The discovery unravels a long­standing evolutionary mystery that could lead to new strategies for treating protein folding diseases such as Alzheimer's and Parkinson's, which occur when proteins misfold or pile up.

"Once we know how to manipulate the levels of polyphosphate in cells and organisms, we should be able to improve protein folding and develop countermeasures against protein folding diseases," said Ursula Jakob, the U-M professor in charge of the research.

Their work appears in the journal Molecular Cell.


Story Source:

The above story is based on materials provided by University of Michigan. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael J. Gray, Wei-Yun Wholey, Nico O. Wagner, Claudia M. Cremers, Antje Mueller-Schickert, Nathaniel T. Hock, Adam G. Krieger, Erica M. Smith, Robert A. Bender, James C.A. Bardwell, Ursula Jakob. Polyphosphate Is a Primordial Chaperone. Molecular Cell, 2014; DOI: 10.1016/j.molcel.2014.01.012

Cite This Page:

University of Michigan. "Chemical chaperones have helped proteins do their jobs for billions of years." ScienceDaily. ScienceDaily, 20 February 2014. <www.sciencedaily.com/releases/2014/02/140220131356.htm>.
University of Michigan. (2014, February 20). Chemical chaperones have helped proteins do their jobs for billions of years. ScienceDaily. Retrieved April 15, 2014 from www.sciencedaily.com/releases/2014/02/140220131356.htm
University of Michigan. "Chemical chaperones have helped proteins do their jobs for billions of years." ScienceDaily. www.sciencedaily.com/releases/2014/02/140220131356.htm (accessed April 15, 2014).

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