Featured Research

from universities, journals, and other organizations

Two micro mechanisms that regulate immune system uncovered

Date:
February 26, 2014
Source:
University of Southern California - Health Sciences
Summary:
Previously unknown interactions between critical proteins in the human immune response system, have been discovered by scientists, uncovering two independent regulatory mechanisms that keep the body's immune response in check. The authors suggest that while they do not yet fully understand this regulatory mechanism, and continue to study it in hopes of harnessing its power to cure disease, it is an important step forward in understanding both what stops the body's immune response, and what activates it.

A Keck Medicine of USC-led team of microbiologists has identified previously unknown interactions between critical proteins in the human immune response system, uncovering two independent regulatory mechanisms that keep the body's immune response in check. Their findings appear in the February 2014 edition of Cell Host & Microbe, the top peer-reviewed scientific journal that focuses on the study of cell-pathogen interaction.

"The body's response to infection consists of a complex network of biological processes set off by the intrusion of disease-causing microbes," said Qiming Liang, Ph.D., USC post-doctoral fellow and study co-author. "This is a powerful response that needs precise regulation to ensure that the host body is not harmed after the pathogen is destroyed."

For this reason, the authors suggest that it is just as important to know what stops the body's immune response as what activates it. Scientists do not yet fully understand this regulatory mechanism and continue to study it in hopes of harnessing its power to cure disease.

"We report that the direct interaction between the cGAS DNA sensor and the Beclin-1 autophagy protein shapes innate immune responses by regulating both the production of the cGAMP molecule and the process that destructs the microbial DNA," said Gil Ju Seo, Ph.D., post-doctoral fellow and study co-author. "This is significant because the cGAMP molecule signals the production of inflammatory cytokines, which kill viruses and bacteria but can also harm the body if uncontrolled."


Story Source:

The above story is based on materials provided by University of Southern California - Health Sciences. The original article was written by Alison Trinidad. Note: Materials may be edited for content and length.


Journal Reference:

  1. Qiming Liang, GilJu Seo, YounJung Choi, Mi-Jeong Kwak, Jianning Ge, MaryA. Rodgers, Mude Shi, BenjaminJ. Leslie, Karl-Peter Hopfner, Taekjip Ha, Byung-Ha Oh, JaeU. Jung. Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Cell Host & Microbe, 2014; 15 (2): 228 DOI: 10.1016/j.chom.2014.01.009

Cite This Page:

University of Southern California - Health Sciences. "Two micro mechanisms that regulate immune system uncovered." ScienceDaily. ScienceDaily, 26 February 2014. <www.sciencedaily.com/releases/2014/02/140226095258.htm>.
University of Southern California - Health Sciences. (2014, February 26). Two micro mechanisms that regulate immune system uncovered. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2014/02/140226095258.htm
University of Southern California - Health Sciences. "Two micro mechanisms that regulate immune system uncovered." ScienceDaily. www.sciencedaily.com/releases/2014/02/140226095258.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins