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Discovery could lead to novel therapies for Fragile X syndrome

Date:
April 17, 2014
Source:
University of California - San Diego
Summary:
Scientists studying the most common form of inherited mental disability -- a genetic disease called 'Fragile X syndrome' -- have uncovered new details about the cellular processes responsible for the condition that could lead to the development of therapies to restore some of the capabilities lost in affected individuals.

The scientists found the FMRP protein (in red) binds to a region of the ribosome—between two ribosomal subunits—likely to be critical for the proper production of many proteins in the brain responsible for normal cognitive function.
Credit: Image courtesy of University of California - San Diego

Scientists studying the most common form of inherited mental disability -- a genetic disease called "Fragile X syndrome" -- have uncovered new details about the cellular processes responsible for the condition that could lead to the development of therapies to restore some of the capabilities lost in affected individuals.

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In a paper that will be published in the May 8 Molecular Cell, but is being made available this week in the early online edition of the journal, the researchers show how the fragile X mental retardation protein, or FMRP, which is in short supply in individuals with Fragile X, affects the protein-making structures of cells in the brain to cause the disease.

Researchers previously knew that in the absence of FMRP, protein-synthesizing structures called ribosomes translated some of the genetic instructions to produce proteins in the brain incorrectly, but exactly how this translation went awry was a mystery.

"The precise mechanism used by FMRP to regulate translation was not known," said Simpson Joseph, a professor of chemistry and biochemistry at UC San Diego and a senior author of the study, which also involved scientists at the State University of New York at Albany and the New York State Department of Health. "Our study shows that FMRP can bind directly to the ribosome to regulate its function."

More precisely, the researchers found that the protein binds to a region of the ribosome -- between two ribosomal subunits -- likely to be critical for the proper production of many proteins in the brain responsible for normal cognitive function. Using laboratory fruit flies, which have FMRP and ribosomes similar to those in humans, the scientists mapped the primary binding site of FMRP on the ribosome. With that information, medical researchers might be able to identify potential drugs that target those areas of the ribosome to help restore normal protein production in individuals with Fragile X.

"Similar to FMRP, it is possible that there are other proteins in the cell that bind directly to the ribosome as well to regulate gene expression," said Joseph.


Story Source:

The above story is based on materials provided by University of California - San Diego. The original article was written by Kim McDonald. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eileen Chen, ManjuliR. Sharma, Xinying Shi, RajendraK. Agrawal, Simpson Joseph. Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome. Molecular Cell, 2014; DOI: 10.1016/j.molcel.2014.03.023

Cite This Page:

University of California - San Diego. "Discovery could lead to novel therapies for Fragile X syndrome." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417124358.htm>.
University of California - San Diego. (2014, April 17). Discovery could lead to novel therapies for Fragile X syndrome. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2014/04/140417124358.htm
University of California - San Diego. "Discovery could lead to novel therapies for Fragile X syndrome." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417124358.htm (accessed March 2, 2015).

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