Featured Research

from universities, journals, and other organizations

Two genes linked to inflammatory bowel disease

Date:
April 22, 2014
Source:
University of Cincinnati Academic Health Center
Summary:
Scientists have done what is believed to be the first direct genetic study to document the important function for the Ron receptor, a cell surface protein often found in certain cancers, and its genetic growth factor, responsible for stimulating cell growth, in the development and progression of inflammatory bowel disease.

Inflammatory Bowel Disease (IBD), a group of chronic inflammatory disorders of the intestine that result in painful and debilitating complications, affects over 1.4 million people in the U.S., and while there are treatments to reduce inflammation for patients, there is no cure.

Related Articles


Now, Cincinnati Cancer Center and University of Cincinnati (UC) Cancer Institute researcher Susan Waltz, PhD, and scientists in her lab have done what is believed to be the first direct genetic study to document the important function for the Ron receptor, a cell surface protein often found in certain cancers, and its genetic growth factor, responsible for stimulating cell growth, in the development and progression of IBD.

These results are published in the advance online edition of the American Journal of Physiology-Gastrointestinal and Liver Physiology.

"Genome-wide linkage studies have identified the Ron receptor tyrosine kinase and its hepatocyte growth factor-like protein (HGFL) as genes highly associated with IBD," says Waltz, professor in the department of cancer biology at UC. "However, only scant information exists on the role of Ron or HGFL in IBD. Based on the linkage of Ron to IBD, we examined the biological role of Ron in colitis."

Colitis is swelling of the large intestine (colon) and is a potentially pre-cancerous condition.

Waltz says that due to her lab's cancer-related expertise with studying Ron and HGFL, she and her colleagues had all of the tools to translate their knowledge of the study of these proteins in IBD.

In the study, Waltz and Rishikesh Kulkarni, PhD, a postdoctoral fellow in UC's department of cancer biology, used animal models with colitis. A genetic knockout group did not have Ron; the other did.

"We found that genetic loss of Ron led to aggressive inflammation and damage to the colon of models with IBD," she says.

Loss of Ron also led to significantly reduced body weight and a dramatic reduction in colon tissue cell growth as well as increased pro-inflammatory cytokine (proteins important in cell signaling) production, which was associated with changes in important signaling pathways known to regulate IBD.

"In addition, there are a number of small changes called single nucleotide polymorphisms (SNP) in humans which map to both the Ron and HGFL gene and have been identified to strongly associate IBD disease in humans," Waltz says. "Our studies suggest that these SNPs may reduce the function of Ron and HGFL leading to chronic intestinal inflammation and damage.

"With the knowledge that we've gained in studying these proteins in cancer biology, we hope this information may be translated to help patients with Crohn's disease and ulcerative colitis. Further studies on the Ron signaling pathway are needed and could reveal an important new target for these conditions."


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. M. Kulkarni, W. D. Stuart, D. Gurusamy, S. E. Waltz. Ron receptor signaling is protective against DSS-induced colitis in mice.. AJP: Gastrointestinal and Liver Physiology, 2014; DOI: 10.1152/ajpgi.00421.2013

Cite This Page:

University of Cincinnati Academic Health Center. "Two genes linked to inflammatory bowel disease." ScienceDaily. ScienceDaily, 22 April 2014. <www.sciencedaily.com/releases/2014/04/140422100103.htm>.
University of Cincinnati Academic Health Center. (2014, April 22). Two genes linked to inflammatory bowel disease. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2014/04/140422100103.htm
University of Cincinnati Academic Health Center. "Two genes linked to inflammatory bowel disease." ScienceDaily. www.sciencedaily.com/releases/2014/04/140422100103.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins