Featured Research

from universities, journals, and other organizations

Hepatitis C virus: How viral proteins interact in human cells

Date:
May 8, 2014
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
For the first time scientists have decrypted the interaction network of hepatitis C virus proteins in living human cells. Their findings will contribute to a better understanding of the mechanisms behind inflammatory liver disease caused by hepatitis C viruses and open up new avenues for therapy development.

Scientists at the Helmholtz Zentrum Mόnchen have for the first time decrypted the interaction network of hepatitis C virus proteins in living human cells. Their findings will contribute to a better understanding of the mechanisms behind inflammatory liver disease caused by hepatitis C viruses and open up new avenues for therapy development. The results are published in the specialist journal Molecular & Cellular Proteomics.

Viruses use human cells in order to multiply and spread. This process involves interactions with cellular host factors as well as virus-virus interactions. For example interactions among viral proteins are essential for the assembly of newly produced infectious virions.

Interaction network explains viral mechanisms and opens up possibilities for new treatments

Hepatitis C virus (HCV) forms a precursor protein, which is processed into ten viral proteins. Scientists at the Institute of Virology at the Helmholtz Zentrum have now discovered how these proteins interact with one another and thus regulate important stages in the viral replication cycle. Shedding light on this interaction network creates a better understanding of the mechanisms underlying viral replication and pathogenesis and paves the way for new antiviral therapies.

As part of their investigations, the team led by Professor Michael Schindler, head of the working group at the Institute of Virology, applied the FACS-FRET technique, which Schindler had developed at the Heinrich Pette Institute in Hamburg. With the aid of FACS-FRET, protein interactions in living cells can be characterized. Furthermore, it allows to unravel the relevance of certain protein interactions for replication. This method also enables screening for antiviral substances.

Finding new antiviral substances with few adverse effects

"Our results show how viral proteins interact within human cells. This provides a basis for identifying new antiviral substances. We propose by specifically targeting virus-virus interactions to find drugs with low cellular toxicity. This hypothesis was already confirmed in first screenings approaches," Schindler explains. "Since our method can be applied in an interdisciplinary manner, we are also aiming to elucidate the networks of other human pathogenic viruses. For instance hepatitis B virus (HBV) or the human immunodeficiency virus (HIV)."

Infections with HCV lead to inflammation of the liver, and in up to 80 percent of cases the inflammation becomes chronic. Hepatitis C is a risk factor for the development of liver cirrhosis and liver cancer.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. Hagen, K. Bayer, K. Roesch, M. Schindler. The intra viral protein interaction network of hepatitis C virus. Molecular & Cellular Proteomics, 2014; DOI: 10.1074/mcp.M113.036301

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Hepatitis C virus: How viral proteins interact in human cells." ScienceDaily. ScienceDaily, 8 May 2014. <www.sciencedaily.com/releases/2014/05/140508110935.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2014, May 8). Hepatitis C virus: How viral proteins interact in human cells. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/05/140508110935.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Hepatitis C virus: How viral proteins interact in human cells." ScienceDaily. www.sciencedaily.com/releases/2014/05/140508110935.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins