Featured Research

from universities, journals, and other organizations

Intake of dietary prenatal folate and other methyl donors in first trimester of pregnancy affects asthma risk in children at age 7

Date:
May 20, 2014
Source:
American Thoracic Society (ATS)
Summary:
Maternal intake of dietary methyl donors during the first trimester of pregnancy modulates the risk of developing childhood asthma at age 7, according to a new study. Methyl donors are nutrients involved in a biochemical process called methylation, in which chemicals are linked to proteins, DNA, or other molecules in the body.

Maternal intake of dietary methyl donors during the first trimester of pregnancy modulates the risk of developing childhood asthma at age 7, according to a new study presented at the 2014 American Thoracic Society International Conference.

"Evidence on the effects of dietary methyl donor intake on childhood asthma has been mixed," said lead author Michelle Trivedi, MD, Clinical Fellow in Pediatric Pulmonology at Massachusetts General Hospital for Children in Boston. "It has been suggested that folate enrichment of some foods may have contributed to the increasing asthma and allergy prevalence in the US. In our study of more than a one thousand mother-child pairs, we found that maternal intake of the six methyl donors we studied, folate, choline, betaine, and vitamins B2, B6, and B12, had protective effects on the risk of developing childhood asthma, and that interactions between these nutrients affected the magnitude and the direction of this risk."

Methyl donors are nutrients involved in a biochemical process called methylation, in which chemicals are linked to proteins, DNA, or other molecules in the body. This process is involved in a number of important functions in the body, and dietary intake of methyl donors has been shown to affect the risk of developing a number of diseases, including heart disease and cancer.

In the current study, maternal dietary and supplemental methyl donor intake was assessed with food-frequency questionnaires in the first and second trimesters in 1,052 mother-child pairs. Of the 1,052 children, 219 (20.8%) were diagnosed with asthma at age 7.

In analyses adjusting for age, body mass index, asthma, education, and household income of the mother along with the birth weight, sex, race/ethnicity, duration of breastfeeding, exposure to environmental tobacco smoke, and eczema of the child, only dietary vitamin B12 and choline in the first trimester were associated with lower asthma prevalence at age 7. "Our results suggest that dietary intake of folate and other methyl donors during pregnancy does not increase the risk for asthma and may, in fact, decrease the risk of offspring developing asthma," said Dr. Trivedi. "Further study is warranted to dissect potential mechanisms." Dr. Trivedi's group is planning further research on the mechanisms by which folate and other methyl donors affect the methylation status of DNA.


Story Source:

The above story is based on materials provided by American Thoracic Society (ATS). Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society (ATS). "Intake of dietary prenatal folate and other methyl donors in first trimester of pregnancy affects asthma risk in children at age 7." ScienceDaily. ScienceDaily, 20 May 2014. <www.sciencedaily.com/releases/2014/05/140520184636.htm>.
American Thoracic Society (ATS). (2014, May 20). Intake of dietary prenatal folate and other methyl donors in first trimester of pregnancy affects asthma risk in children at age 7. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2014/05/140520184636.htm
American Thoracic Society (ATS). "Intake of dietary prenatal folate and other methyl donors in first trimester of pregnancy affects asthma risk in children at age 7." ScienceDaily. www.sciencedaily.com/releases/2014/05/140520184636.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins