Featured Research

from universities, journals, and other organizations

Dietary changes in wild house mice quickly shift their intestinal microbiome composition

Date:
June 3, 2014
Source:
Christian-Albrechts-Universitaet zu Kiel
Summary:
Understanding the reasons why intestinal bacterial communities differ between individuals and within individuals over time represent major challenges for microbiome researchers. Researchers reveal that the recent dietary history of house mice living in the wild is a major determinant of the type of bacterial community present in their gut at a given time.

Understanding the reasons why intestinal bacterial communities differ between individuals and within individuals over time represent major challenges for microbiome researchers. Researchers at Kiel University and the Max Planck Institute for Evolutionary Biology in Germany reveal that the recent dietary history of house mice living in the wild is a major determinant of the type of bacterial community present in their gut at a given time. The article appeared on May, 27th 2014 in the online edition of Proceedings of the National Academy of Sciences.

Related Articles


As part of the German Research Foundation's Cluster of Excellence "Inflammation at Interfaces," the team including evolutionary biologists and microbiologists were motivated to gain a greater understanding of intestinal bacterial community dynamics in the house mouse, which is an important model organism for studying chronic inflammatory disorders such as inflammatory bowel disease.

To gain insight, the researchers turned to house mice in their natural environment, where they encounter a variety of different food sources. Their analyses revealed that similar to recent studies in humans, individual mice could be classified into one of two clusters of bacterial community types, a concept known as "enterotypes."

"What really lead us down the path to understanding these two community types were observations made between free-living mice and those moved to the lab and given a standard lab chow diet," says Professor John Baines, the senior author of the study. "While both mouse enterotypes were consistently present in the wild, mice housed in the lab had only one of these enterotypes."

Interestingly, the single lab-associated mouse enterotype displayed characteristics similar to an analogous enterotype in humans that is associated with greater carbohydrate consumption. To test this possibility in mice, the researchers next turned to colleagues conducting archaeological research at Kiel University, who used their recently developed statistical method to help reconstruct the diet of wild mice using chemical signatures left behind in their tissues.

"Indeed, the wild mice display significant differences in the relative intake of carbohydrate-rich food sources according to their enterotype classification," says Doctor Ricardo Fernandes, a member of Kiel University's Graduate School "Human Development in Landscapes."

Further, the researchers were able to document shifts in enterotype status within one week. The authors acknowledge that more intensive future research is necessary to understand the dynamics of human enterotypes, but speculate that the fast metabolism of a small mammal such as the mouse may play a role.


Story Source:

The above story is based on materials provided by Christian-Albrechts-Universitaet zu Kiel. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Wang, M. Linnenbrink, S. Kunzel, R. Fernandes, M.-J. Nadeau, P. Rosenstiel, J. F. Baines. Dietary history contributes to enterotype-like clustering and functional metagenomic content in the intestinal microbiome of wild mice. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1402342111

Cite This Page:

Christian-Albrechts-Universitaet zu Kiel. "Dietary changes in wild house mice quickly shift their intestinal microbiome composition." ScienceDaily. ScienceDaily, 3 June 2014. <www.sciencedaily.com/releases/2014/06/140603092334.htm>.
Christian-Albrechts-Universitaet zu Kiel. (2014, June 3). Dietary changes in wild house mice quickly shift their intestinal microbiome composition. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2014/06/140603092334.htm
Christian-Albrechts-Universitaet zu Kiel. "Dietary changes in wild house mice quickly shift their intestinal microbiome composition." ScienceDaily. www.sciencedaily.com/releases/2014/06/140603092334.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins