Featured Research

from universities, journals, and other organizations

Inflammation in fat tissue helps prevent metabolic disease

Date:
June 18, 2014
Source:
UT Southwestern Medical Center
Summary:
Chronic tissue inflammation is typically associated with obesity and metabolic disease, but new research now finds that a level of “healthy” inflammation is necessary to prevent metabolic diseases, such as fatty liver. "This finding may explain in part why anti-inflammatory medicines have so far not been successful as anti-diabetic treatments. The effects of interventions that promote local low-level inflammation in fat tissue remain to be determined," researchers said.

Chronic tissue inflammation is typically associated with obesity and metabolic disease, but new research from UT Southwestern Medical Center now finds that a level of "healthy" inflammation is necessary to prevent metabolic diseases, such as fatty liver.

"There is such a thing as 'healthy' inflammation, meaning inflammation that allows the tissue to grow and has overall benefits to the tissue itself and the whole body," said Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research and Professor of Internal Medicine and Cell Biology at UT Southwestern. "The same principle also applies in muscle: Exercise induces some inflammation in the tissue, but also leads to better and stronger muscles and, consequently, a healthier organism."

Using animal models, Dr. Scherer and his team, with first author, Dr. Ingrid Wernstedt Asterholm, former Assistant Instructor at UT Southwestern and current Assistant Professor at the University of Gothenburg in Sweden, found that suppressing inflammation in fat tissue results in reduced fat expansion and thus leaner mice, even when the animals are fed a high-fat diet. The findings were first published online June 12 in Cell Metabolism.

What Dr. Scherer, holder of the Gifford O. Touchstone, Jr. and Randolph G. Touchstone Distinguished Chair in Diabetes Research, and his team expected to find that the reduced body fat content would lead to improvements in metabolism and a lower incidence of metabolic disease. Unexpectedly, the team found that the lean mice showed symptoms of metabolic disease, such as glucose intolerance.

This result might be because when fat tissue expands, it absorbs excess lipids, preventing them from being deposited in other tissues, such as the liver. Indeed, the animal models showed signs of fatty liver, caused by buildup of fat in liver cells, and a "leaky gut," caused by disruption of the gut wall.

"What our research shows is that we need some localized inflammation to remodel our fat tissue and to prevent metabolic diseases such as fatty liver," said Dr. Asterholm. "This finding may explain in part why anti-inflammatory medicines have so far not been successful as anti-diabetic treatments. The effects of interventions that promote local low-level inflammation in fat tissue remain to be determined."


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ingrid WernstedtAsterholm, Caroline Tao, ThomasS. Morley, QiongA. Wang, Fernando Delgado-Lopez, ZhaoV. Wang, PhilippE. Scherer. Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling. Cell Metabolism, 2014; DOI: 10.1016/j.cmet.2014.05.005

Cite This Page:

UT Southwestern Medical Center. "Inflammation in fat tissue helps prevent metabolic disease." ScienceDaily. ScienceDaily, 18 June 2014. <www.sciencedaily.com/releases/2014/06/140618135836.htm>.
UT Southwestern Medical Center. (2014, June 18). Inflammation in fat tissue helps prevent metabolic disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/06/140618135836.htm
UT Southwestern Medical Center. "Inflammation in fat tissue helps prevent metabolic disease." ScienceDaily. www.sciencedaily.com/releases/2014/06/140618135836.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins