Featured Research

from universities, journals, and other organizations

High doses of antibiotics may have potential to promote increased cross-resistance

Date:
June 24, 2014
Source:
Molecular Biology and Evolution (Oxford University Press)
Summary:
An experimental evolution approach has been used by researchers to evolve 88 different E. coli populations against 22 antibiotics, under 'strong' and 'mild' selection conditions. Results demonstrate that the evolution of cross-resistance depends on selection strength. Overall, they found evidence for higher cross-resistance in the strongly selected strains and higher numbers of pathway-specific mutations.

Antibiotic resistance has become an increasing public health concern, with MRSA infections and last lines of antibiotic drug treatments having to be increasingly deployed in hospitals and clinics.

Related Articles


In the advanced online edition of Molecular Biology and Evolution, Oz, et. al., utilized an experimental evolution approach to evolve 88 different E. coli populations against 22 antibiotics, under "strong" and "mild" selection conditions. After 21 days, they isolated bacterial clones, measured the resistance to each antibiotic, and performed whole-genome sequencing of resistance clones to tease out the genetic changes that could be responsible for antibiotic resistance.

Their results demonstrate that the evolution of cross-resistance depends on selection strength. Overall, they found evidence for higher cross-resistance in the strongly selected strains and higher numbers of pathway-specific mutations. The study yielded important new insights into the increased emergence of drug resistance with the use of high doses of antibiotics, as well as hypersensitivities to exploit for new antibiotic therapies.


Story Source:

The above story is based on materials provided by Molecular Biology and Evolution (Oxford University Press). Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Oz, A. Guvenek, S. Yildiz, E. Karaboga, Y. T. Tamer, N. Mumcuyan, V. B. Ozan, G. H. Senturk, M. Cokol, P. Yeh, E. Toprak. Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolution. Molecular Biology and Evolution, 2014; DOI: 10.1093/molbev/msu191

Cite This Page:

Molecular Biology and Evolution (Oxford University Press). "High doses of antibiotics may have potential to promote increased cross-resistance." ScienceDaily. ScienceDaily, 24 June 2014. <www.sciencedaily.com/releases/2014/06/140624220023.htm>.
Molecular Biology and Evolution (Oxford University Press). (2014, June 24). High doses of antibiotics may have potential to promote increased cross-resistance. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2014/06/140624220023.htm
Molecular Biology and Evolution (Oxford University Press). "High doses of antibiotics may have potential to promote increased cross-resistance." ScienceDaily. www.sciencedaily.com/releases/2014/06/140624220023.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Reuters - Innovations Video Online (Jan. 30, 2015) A nanosensor that mimics the oral effects and sensations of drinking wine has been developed by Danish and Portuguese researchers. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Discovery Of 'Dragon' Dinosaur In China Could Explain Myths

Discovery Of 'Dragon' Dinosaur In China Could Explain Myths

Newsy (Jan. 30, 2015) A long-necked dinosaur from the Jurassic Period was discovered in China. Researchers think it could answer mythology questions. Video provided by Newsy
Powered by NewsLook.com
Poll Says Firstborn Is Responsible, Youngest Is Funnier

Poll Says Firstborn Is Responsible, Youngest Is Funnier

Newsy (Jan. 30, 2015) According to a poll out of the U.K., eldest siblings feel more responsible and successful than their younger siblings. Video provided by Newsy
Powered by NewsLook.com
Brawling Pandas Are Violently Adorable

Brawling Pandas Are Violently Adorable

Buzz60 (Jan. 29, 2015) Video of pandas play fighting at the Chengdu Research Base in China will make your day. Mara Montalbano (@maramontalbano) shows us. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins