Featured Research

from universities, journals, and other organizations

High doses of antibiotics may have potential to promote increased cross-resistance

Date:
June 24, 2014
Source:
Molecular Biology and Evolution (Oxford University Press)
Summary:
An experimental evolution approach has been used by researchers to evolve 88 different E. coli populations against 22 antibiotics, under 'strong' and 'mild' selection conditions. Results demonstrate that the evolution of cross-resistance depends on selection strength. Overall, they found evidence for higher cross-resistance in the strongly selected strains and higher numbers of pathway-specific mutations.

Antibiotic resistance has become an increasing public health concern, with MRSA infections and last lines of antibiotic drug treatments having to be increasingly deployed in hospitals and clinics.

In the advanced online edition of Molecular Biology and Evolution, Oz, et. al., utilized an experimental evolution approach to evolve 88 different E. coli populations against 22 antibiotics, under "strong" and "mild" selection conditions. After 21 days, they isolated bacterial clones, measured the resistance to each antibiotic, and performed whole-genome sequencing of resistance clones to tease out the genetic changes that could be responsible for antibiotic resistance.

Their results demonstrate that the evolution of cross-resistance depends on selection strength. Overall, they found evidence for higher cross-resistance in the strongly selected strains and higher numbers of pathway-specific mutations. The study yielded important new insights into the increased emergence of drug resistance with the use of high doses of antibiotics, as well as hypersensitivities to exploit for new antibiotic therapies.


Story Source:

The above story is based on materials provided by Molecular Biology and Evolution (Oxford University Press). Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Oz, A. Guvenek, S. Yildiz, E. Karaboga, Y. T. Tamer, N. Mumcuyan, V. B. Ozan, G. H. Senturk, M. Cokol, P. Yeh, E. Toprak. Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolution. Molecular Biology and Evolution, 2014; DOI: 10.1093/molbev/msu191

Cite This Page:

Molecular Biology and Evolution (Oxford University Press). "High doses of antibiotics may have potential to promote increased cross-resistance." ScienceDaily. ScienceDaily, 24 June 2014. <www.sciencedaily.com/releases/2014/06/140624220023.htm>.
Molecular Biology and Evolution (Oxford University Press). (2014, June 24). High doses of antibiotics may have potential to promote increased cross-resistance. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/06/140624220023.htm
Molecular Biology and Evolution (Oxford University Press). "High doses of antibiotics may have potential to promote increased cross-resistance." ScienceDaily. www.sciencedaily.com/releases/2014/06/140624220023.htm (accessed October 22, 2014).

Share This



More Plants & Animals News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Working Mother DIY: Pumpkin Pom-Pom

Working Mother DIY: Pumpkin Pom-Pom

Working Mother (Oct. 22, 2014) How to make a pumpkin pom-pom. Video provided by Working Mother
Powered by NewsLook.com
San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

Reuters - Light News Video Online (Oct. 22, 2014) The pair of rare white northern rhinos bring hope for their species as only six remain in the world. Elly Park reports. Video provided by Reuters
Powered by NewsLook.com
Raw: Bear Cub Strolls Through Oregon Drug Store

Raw: Bear Cub Strolls Through Oregon Drug Store

AP (Oct. 22, 2014) Shoppers at an Oregon drug store were surprised by a bear cub scurrying down the aisles this past weekend. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Family Pleads for Pet Pig to Stay at Home

Family Pleads for Pet Pig to Stay at Home

AP (Oct. 22, 2014) The Johnson family lost their battle with the Chesterfield County, Virginia Planning Commission to allow Tucker, their pet pig, to stay in their home, but refuse to let the board keep Tucker away. (Oct. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins