Featured Research

from universities, journals, and other organizations

Gene discovered that activates stem cells for organ regeneration in Planarians

Date:
July 3, 2014
Source:
PLOS
Summary:
Researchers announced the discovery of a gene zic-1 that enables stem cells to regrow a head after decapitation in flatworm planarians. Many species across the animal kingdom have the ability to regenerate, but the mechanisms that connect injuries to stem cell activation and the production of new tissues are not fully understood.

The animal on the left is a normal worm that successfully regenerated a head and tail (white/unpigmented tissue). In the animal on the right, the zic-1 gene was inactivated, which prevented head regeneration.
Credit: Christian Petersen

Researchers announced the discovery of a gene zic-1 that enables stem cells to regrow a head after decapitation in flatworm planarians. Professor Christian Petersen and Ph.D. student Constanza Vásquez-Doorman of Northwestern University discovered zic-1 by investigating planarians, an animal that uses pluripotent stem cells to regrow any missing tissue lost from injury.

Related Articles


The study, entitled "zic-1 Expression in Planarian Neoblasts after Injury Controls Anterior Pole Regeneration," was reported in PLOS Genetics.

Many species across the animal kingdom have the ability to regenerate, but the mechanisms that connect injuries to stem cell activation and the production of new tissues are not fully understood. Developmental biologists have established that in the early embryo most animals use "tissue organizers" that secrete proteins to allow cell-cell communication for the formation of organs. But it was not clear how such tissue organizers could be produced from scratch to allow adult regeneration in animals like planarians.

A clue to the solution came from Petersen's previous research that identified the secreted protein Notum as a component of a tissue organizer needed for head regeneration in planarians. Notum drives head regeneration by inhibiting Wnt signaling, a broadly used molecular pathway used in cell-cell communication. Vásquez-Doorman and Petersen found that expression of the Notum protein and head regeneration required the zic-1 gene, which encodes a DNA-binding protein activated in stem cells early after decapitation.

Human stem cells could ultimately be used to build or repair complex tissues, but most ongoing research on these cells has focused on their ability to create individual cell types in a dish. Petersen's study identifies a potentially ancient connection between Wnt signaling and zic-1 in the use of stem cells for coordinating regenerative growth and suggests that human stem cells might someday be used to create tissue organizers for enhancement of injury repair.


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Constanza Vásquez-Doorman, Christian P. Petersen. zic-1 Expression in Planarian Neoblasts after Injury Controls Anterior Pole Regeneration. PLoS Genetics, 2014; 10 (7): e1004452 DOI: 10.1371/journal.pgen.1004452

Cite This Page:

PLOS. "Gene discovered that activates stem cells for organ regeneration in Planarians." ScienceDaily. ScienceDaily, 3 July 2014. <www.sciencedaily.com/releases/2014/07/140703142348.htm>.
PLOS. (2014, July 3). Gene discovered that activates stem cells for organ regeneration in Planarians. ScienceDaily. Retrieved April 17, 2015 from www.sciencedaily.com/releases/2014/07/140703142348.htm
PLOS. "Gene discovered that activates stem cells for organ regeneration in Planarians." ScienceDaily. www.sciencedaily.com/releases/2014/07/140703142348.htm (accessed April 17, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, April 17, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) — A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) — Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dog Flu Spreading in Midwestern States

Dog Flu Spreading in Midwestern States

AP (Apr. 17, 2015) — Dog flu is spreading in several Midwestern states. Dog daycare centers and veterinary offices are taking precautions. (April 17) Video provided by AP
Powered by NewsLook.com
Raw: Rare Whale Spotted in Gulf of Mexico

Raw: Rare Whale Spotted in Gulf of Mexico

AP (Apr. 17, 2015) — Researchers from the E/V Nautilus had quite a surprise Tuesday, when a curious sperm whale swam around their remotely operated vehicle in the Gulf of Mexico. Cameras captured the encounter. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins