Featured Research

from universities, journals, and other organizations

New optogenetic tool for controlling neuronal signalling by blue light

Date:
July 5, 2014
Source:
Institute for Basic Science
Summary:
Scientists have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology “OptoTrk” and it has succeeded with neuronal differentiation inducement.

Institute for Basic Science (IBS) has announced that a group of researchers, led by Professor Won Do Heo, have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology "OptoTrk" and it has succeeded with neuronal differentiation inducement.

Related Articles


The most significant feature of OptoTrk technology is that it requires only light to activate neuronal functions without the need of other substances. The receptors are activated when exposed to blue light, and then induce both neuronal growth and differentiation by upregulating downstream cell signalling.

Before the development of this new technology, natural ligands or agonists were widely used as tools to specifically control receptor activity. However, they did not allow spatiotemporal control, and so required a time period to bind with the receptor. Therefore, there were limits to understanding the dynamic nature of intracellular signalling networks. To address these limitations, the researchers developed this new technology using optogenetics. Recently optogenetics is attracting attention from many, various fields in the biological sciences. This study applies light-sensitive proteins -- found in microorganisms and plants -- to human (and/or animal) cells and can manipulate several cell functions.

"We are now conducting neuroscience research on several mouse models using our OptoTrk technology," says professor Won Do Heo who led the research. "This newly developed technology will play a ground-breaking role in investigating the functions of neurons in the brain, specifically those functions in the most complicated of neural networks, which existing technologies have limitations exploring."

Professor Won Do Heo added that he plans to publish an additional paper related to source technology by the end of June. This will bring the Professor's number of published research outcomes related to the study of optogenetics to a total of 3 in the last two months. These publications include the paper regarding "Light-Activated Reversible Inhibition by Assembled Trap (LARIAT)." This paper on LARIAT was published in May in the prominent science journal, Nature Method, in the field of biochemistry.


Story Source:

The above story is based on materials provided by Institute for Basic Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ki-Young Chang, Doyeon Woo, Hyunjin Jung, Sangkyu Lee, Sungsoo Kim, Joungha Won, Taeyoon Kyung, Hyerim Park, Nury Kim, Hee Won Yang, Jae-Yong Park, Eun Mi Hwang, Daesoo Kim, Won Do Heo. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nature Communications, 2014; 5 DOI: 10.1038/ncomms5057

Cite This Page:

Institute for Basic Science. "New optogenetic tool for controlling neuronal signalling by blue light." ScienceDaily. ScienceDaily, 5 July 2014. <www.sciencedaily.com/releases/2014/07/140705140057.htm>.
Institute for Basic Science. (2014, July 5). New optogenetic tool for controlling neuronal signalling by blue light. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2014/07/140705140057.htm
Institute for Basic Science. "New optogenetic tool for controlling neuronal signalling by blue light." ScienceDaily. www.sciencedaily.com/releases/2014/07/140705140057.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

MINI Shows Off Augmented Reality Glasses

MINI Shows Off Augmented Reality Glasses

AP (Apr. 24, 2015) — MINI showcased its new augmented reality glasses at the Shanghai Auto Show this week, which designers say will make roads safer and allow the driver to see through opaque parts of the car. (April 24) Video provided by AP
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) — Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com
'Safest Bike Ever' Devised by British Entrepreneur

'Safest Bike Ever' Devised by British Entrepreneur

Reuters - Innovations Video Online (Apr. 23, 2015) — A British inventor says his Babel bike is the safest bicycle ever produced. Crispin Sinclair - son of famous British inventor Sir Clive Sinclair - hopes the bike&apos;s safety cage, double seatbelt, and host of other measures will inspire non-cyclists to get in the saddle. Jim Drury went to see it in action. Video provided by Reuters
Powered by NewsLook.com
First Successful Aerial Refueling of a Drone

First Successful Aerial Refueling of a Drone

Reuters - Innovations Video Online (Apr. 23, 2015) — The bat-wing U.S. Navy drone that became the first autonomous airplane to take off and land on an aircraft carrier accomplished yet another milestone on Wednesday, becoming the first unmanned aircraft to undergo aerial refueling. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins