Featured Research

from universities, journals, and other organizations

New optogenetic tool for controlling neuronal signalling by blue light

Date:
July 5, 2014
Source:
Institute for Basic Science
Summary:
Scientists have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology “OptoTrk” and it has succeeded with neuronal differentiation inducement.

Institute for Basic Science (IBS) has announced that a group of researchers, led by Professor Won Do Heo, have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology "OptoTrk" and it has succeeded with neuronal differentiation inducement.

The most significant feature of OptoTrk technology is that it requires only light to activate neuronal functions without the need of other substances. The receptors are activated when exposed to blue light, and then induce both neuronal growth and differentiation by upregulating downstream cell signalling.

Before the development of this new technology, natural ligands or agonists were widely used as tools to specifically control receptor activity. However, they did not allow spatiotemporal control, and so required a time period to bind with the receptor. Therefore, there were limits to understanding the dynamic nature of intracellular signalling networks. To address these limitations, the researchers developed this new technology using optogenetics. Recently optogenetics is attracting attention from many, various fields in the biological sciences. This study applies light-sensitive proteins -- found in microorganisms and plants -- to human (and/or animal) cells and can manipulate several cell functions.

"We are now conducting neuroscience research on several mouse models using our OptoTrk technology," says professor Won Do Heo who led the research. "This newly developed technology will play a ground-breaking role in investigating the functions of neurons in the brain, specifically those functions in the most complicated of neural networks, which existing technologies have limitations exploring."

Professor Won Do Heo added that he plans to publish an additional paper related to source technology by the end of June. This will bring the Professor's number of published research outcomes related to the study of optogenetics to a total of 3 in the last two months. These publications include the paper regarding "Light-Activated Reversible Inhibition by Assembled Trap (LARIAT)." This paper on LARIAT was published in May in the prominent science journal, Nature Method, in the field of biochemistry.


Story Source:

The above story is based on materials provided by Institute for Basic Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ki-Young Chang, Doyeon Woo, Hyunjin Jung, Sangkyu Lee, Sungsoo Kim, Joungha Won, Taeyoon Kyung, Hyerim Park, Nury Kim, Hee Won Yang, Jae-Yong Park, Eun Mi Hwang, Daesoo Kim, Won Do Heo. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nature Communications, 2014; 5 DOI: 10.1038/ncomms5057

Cite This Page:

Institute for Basic Science. "New optogenetic tool for controlling neuronal signalling by blue light." ScienceDaily. ScienceDaily, 5 July 2014. <www.sciencedaily.com/releases/2014/07/140705140057.htm>.
Institute for Basic Science. (2014, July 5). New optogenetic tool for controlling neuronal signalling by blue light. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/07/140705140057.htm
Institute for Basic Science. "New optogenetic tool for controlling neuronal signalling by blue light." ScienceDaily. www.sciencedaily.com/releases/2014/07/140705140057.htm (accessed September 21, 2014).

Share This



More Matter & Energy News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

What This MIT Sensor Could Mean For The Future Of Robotics

What This MIT Sensor Could Mean For The Future Of Robotics

Newsy (Sep. 20, 2014) MIT researchers developed a light-based sensor that gives robots 100 times the sensitivity of a human finger, allowing for "unprecedented dexterity." Video provided by Newsy
Powered by NewsLook.com
MIT BioSuit A New Take On Traditional Spacesuits

MIT BioSuit A New Take On Traditional Spacesuits

Newsy (Sep. 19, 2014) The MIT BioSuit could be an alternative to big, bulky traditional spacesuits, but the concept needs some work. Video provided by Newsy
Powered by NewsLook.com
New Music With Recycled Instruments at Colombia Fest

New Music With Recycled Instruments at Colombia Fest

AFP (Sep. 19, 2014) Jars, bottles, caps and even a pizza box, recovered from the trash, were the elements used by four musical groups at the "RSFEST2014 Sonorities Recycling Festival", in Colombian city of Cali. Duration: 00:49 Video provided by AFP
Powered by NewsLook.com
Virtual Reality Headsets Unveiled at Tokyo Game Show

Virtual Reality Headsets Unveiled at Tokyo Game Show

AFP (Sep. 18, 2014) Several companies unveiled virtual reality headsets at the Tokyo Game Show, Asia's largest digital entertainment exhibition. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins