Featured Research

from universities, journals, and other organizations

New optogenetic tool for controlling neuronal signalling by blue light

Date:
July 5, 2014
Source:
Institute for Basic Science
Summary:
Scientists have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology “OptoTrk” and it has succeeded with neuronal differentiation inducement.

Institute for Basic Science (IBS) has announced that a group of researchers, led by Professor Won Do Heo, have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology "OptoTrk" and it has succeeded with neuronal differentiation inducement.

The most significant feature of OptoTrk technology is that it requires only light to activate neuronal functions without the need of other substances. The receptors are activated when exposed to blue light, and then induce both neuronal growth and differentiation by upregulating downstream cell signalling.

Before the development of this new technology, natural ligands or agonists were widely used as tools to specifically control receptor activity. However, they did not allow spatiotemporal control, and so required a time period to bind with the receptor. Therefore, there were limits to understanding the dynamic nature of intracellular signalling networks. To address these limitations, the researchers developed this new technology using optogenetics. Recently optogenetics is attracting attention from many, various fields in the biological sciences. This study applies light-sensitive proteins -- found in microorganisms and plants -- to human (and/or animal) cells and can manipulate several cell functions.

"We are now conducting neuroscience research on several mouse models using our OptoTrk technology," says professor Won Do Heo who led the research. "This newly developed technology will play a ground-breaking role in investigating the functions of neurons in the brain, specifically those functions in the most complicated of neural networks, which existing technologies have limitations exploring."

Professor Won Do Heo added that he plans to publish an additional paper related to source technology by the end of June. This will bring the Professor's number of published research outcomes related to the study of optogenetics to a total of 3 in the last two months. These publications include the paper regarding "Light-Activated Reversible Inhibition by Assembled Trap (LARIAT)." This paper on LARIAT was published in May in the prominent science journal, Nature Method, in the field of biochemistry.


Story Source:

The above story is based on materials provided by Institute for Basic Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ki-Young Chang, Doyeon Woo, Hyunjin Jung, Sangkyu Lee, Sungsoo Kim, Joungha Won, Taeyoon Kyung, Hyerim Park, Nury Kim, Hee Won Yang, Jae-Yong Park, Eun Mi Hwang, Daesoo Kim, Won Do Heo. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nature Communications, 2014; 5 DOI: 10.1038/ncomms5057

Cite This Page:

Institute for Basic Science. "New optogenetic tool for controlling neuronal signalling by blue light." ScienceDaily. ScienceDaily, 5 July 2014. <www.sciencedaily.com/releases/2014/07/140705140057.htm>.
Institute for Basic Science. (2014, July 5). New optogenetic tool for controlling neuronal signalling by blue light. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/07/140705140057.htm
Institute for Basic Science. "New optogenetic tool for controlling neuronal signalling by blue light." ScienceDaily. www.sciencedaily.com/releases/2014/07/140705140057.htm (accessed July 31, 2014).

Share This




More Matter & Energy News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Britain Testing Driverless Cars on Roadways

Britain Testing Driverless Cars on Roadways

AP (July 30, 2014) British officials said on Wednesday that driverless cars will be tested on roads in as many as three cities in a trial program set to begin in January. Officials said the tests will last up to three years. (July 30) Video provided by AP
Powered by NewsLook.com
Amid Drought, UCLA Sees Only Water

Amid Drought, UCLA Sees Only Water

AP (July 30, 2014) A ruptured 93-year-old water main left the UCLA campus awash in 8 million gallons of water in the middle of California's worst drought in decades. (July 30) Video provided by AP
Powered by NewsLook.com
Smartphone Powered Paper Plane Debuts at Airshow

Smartphone Powered Paper Plane Debuts at Airshow

AP (July 30, 2014) Smartphone powered paper airplane that was popular on crowdfunding website KickStarter makes its debut at Wisconsin airshow (July 30) Video provided by AP
Powered by NewsLook.com
U.K. To Allow Driverless Cars On Public Roads

U.K. To Allow Driverless Cars On Public Roads

Newsy (July 30, 2014) Driverless cars could soon become a staple on U.K. city streets, as they're set to be introduced to a few cities in 2015. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins