Featured Research

from universities, journals, and other organizations

Animal vaccines should guide malaria research, experts say

Date:
July 7, 2014
Source:
University of Adelaide
Summary:
Research into vaccines for malaria in humans should be guided by the success shown in producing effective vaccines for malaria-like diseases in animals, according to a research study. A veterinarian and disease researcher says there are many effective vaccines for diseases in animals caused by close relatives of the parasites that cause malaria (called protozoans). "In contrast, there are no vaccines available for malaria or any other protozoal disease of humans - despite great need and considerable effort," he says.

Research into vaccines for malaria in humans should be guided by the success shown in producing effective vaccines for malaria-like diseases in animals, according to a University of Adelaide study.

Related Articles


In an article in the journal Parasitology, veterinarian and disease researcher Associate Professor Milton McAllister says there are many effective vaccines for diseases in animals caused by close relatives of the parasites that cause malaria (called protozoans).

"In contrast, there are no vaccines available for malaria or any other protozoal disease of humans - despite great need and considerable effort," he says. Associate Professor McAllister is with the University's School of Animal and Veterinary Sciences.

"There is one vaccine in development for malaria - but that requires three inoculations and only about half the people vaccinated are protected, and that protection only lasts for about six months. Vaccines for similar diseases in cattle and sheep, on the other hand, require only one inoculation and provide solid immunity that endures for more than a year and often covers the life of the animal."

The World Health Organization reports that malaria kills more than 600,000 people a year out of about 200 million infections.

"For human malaria, great emphasis has been placed on creating new types of futuristic vaccines using small pieces of DNA and protein from the disease-causing parasite," says Associate Professor McAllister. "There is a great desire to make malaria vaccines very safe - as they should be - but that approach has just not been effective."

In contrast, vaccines for animals contain entire organisms in a live but weakened form. "Using live vaccines has produced considerable success in a range of malaria-like diseases in animals," he says.

A few of the many successful examples in animals include several vaccines for blood parasites of livestock such as babesiosis, which has seen greater than 90% reduction of the disease in Australia and other countries, tropical theileriosis in Southern Europe and Asia, and East Coast Fever in Africa.

"Using live organisms and classical vaccine technology has worked very well in veterinary medicine, providing enduring immunity against a range of serious diseases," Associate Professor McAllister says. "Human medicine is missing significant benefits by not paying greater attention to veterinary knowledge.

"Funding for human malaria research should place greater emphasis on creating vaccines that contain live but weakened parasites. This classical vaccine approach should be highly effective. Cutting-edge techniques are available to ensure that these vaccines will be safe."


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. MILTON M. MCALLISTER. Successful vaccines for naturally occurring protozoal diseases of animals should guide human vaccine research. A review of protozoal vaccines and their designs. Parasitology, 2014; 141 (05): 624 DOI: 10.1017/S0031182013002060

Cite This Page:

University of Adelaide. "Animal vaccines should guide malaria research, experts say." ScienceDaily. ScienceDaily, 7 July 2014. <www.sciencedaily.com/releases/2014/07/140707092324.htm>.
University of Adelaide. (2014, July 7). Animal vaccines should guide malaria research, experts say. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2014/07/140707092324.htm
University of Adelaide. "Animal vaccines should guide malaria research, experts say." ScienceDaily. www.sciencedaily.com/releases/2014/07/140707092324.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins