Featured Research

from universities, journals, and other organizations

New leads for liver disease treatments: Strict genomic partitioning by biological clock separates key metabolic functions

Date:
July 31, 2014
Source:
University of California - Irvine
Summary:
Much of the liver's metabolic function is governed by circadian rhythms -- our own body clock -- and researchers have now found two independent mechanisms by which this occurs.

Much of the liver's metabolic function is governed by circadian rhythms -- our own body clock -- and UC Irvine researchers have now found two independent mechanisms by which this occurs.

Related Articles


The study, published online today in Cell, reveals new information about the body clock's sway over metabolism and points the way to more focused drug treatments for liver disease and such metabolic disorders as obesity and diabetes.

Paolo Sassone-Corsi, UCI's Donald Bren Professor of Biological Chemistry, and postdoctoral scholar Selma Masri report that two of these circadian-linked proteins, SIRT1 and SIRT6, manage important liver processes -- lipid storage and energy usage in liver cells -- separately and distinctly from each other.

This surprising discovery of genomic partitioning, Masri noted, reveals how strictly regulated circadian control of metabolism can be.

"The ability of the genome and epigenome to cross-talk with metabolic pathways is critical for cellular and organismal functions. What's remarkable is that the circadian clock is intimately involved in this dialogue," she said.

Circadian rhythms of 24 hours govern fundamental physiological functions in virtually all organisms. The circadian clocks are intrinsic time-tracking systems in our bodies that anticipate environmental changes and adapt themselves to the appropriate time of day. Changes to these rhythms can profoundly influence human health. Up to 15 percent of people's genes are regulated by the day-night pattern of circadian rhythms; nearly 50 percent of those involved with metabolic pathways in the liver are influenced by these rhythms.

SIRT1 and SIRT6 belong to a group of proteins called sirtuins that participate in epigenetic control of the genome and help regulate important biological processes ranging from cell health maintenance to lipid storage and energy expenditure in cells. They're widely studied for their effect on metabolism and longevity.

To discover how SIRT1 and SIRT6 work independently of each other, Masri and Sassone-Corsi conducted tests with two sets of mice -- one with SIRT1 in the liver knocked out and the other with SIRT6 nullified.

The two sirtuins, the scientists learned, are committed to the control of distinct genomic domains, with hundreds of genes being SIRT1-dependent and hundreds of others relying on SIRT6. This resulted in a distinct partition of metabolic pathways and physiological functions, Sassone-Corsi said.

He added that these findings pave the way to further investigations that may facilitate the design of pharmacological strategies targeting SIRT1- or SIRT6-specific metabolic functions and pathologies.

Paul Rigor, Marlene Cervantes, Nicholas Ceglia and Pierre Baldi of UC Irvine; Carlos Sebastian and Raul Mostoslavsky of Harvard Medical School; Cuiying Xiao and Chuxia Deng of the National Institutes of Health; and Timothy Osborne of the Sanford-Burnham Medical Research Institute in Orlando, Fla., contributed to the study, which received support from the National Institutes of Health (grants GM097899, LM010235, LM07443 and AG043745), the National Science Foundation (grant IIS-1321053), the Merieux Research Institute and Sirtris Pharmaceuticals.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Selma Masri, Paul Rigor, Marlene Cervantes, Nicholas Ceglia, Carlos Sebastian, Cuiying Xiao, Manuel Roqueta-Rivera, Chuxia Deng, Timothy F. Osborne, Raul Mostoslavsky, Pierre Baldi, Paolo Sassone-Corsi. Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism. Cell, 2014; 158 (3): 659 DOI: 10.1016/j.cell.2014.06.050

Cite This Page:

University of California - Irvine. "New leads for liver disease treatments: Strict genomic partitioning by biological clock separates key metabolic functions." ScienceDaily. ScienceDaily, 31 July 2014. <www.sciencedaily.com/releases/2014/07/140731145931.htm>.
University of California - Irvine. (2014, July 31). New leads for liver disease treatments: Strict genomic partitioning by biological clock separates key metabolic functions. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2014/07/140731145931.htm
University of California - Irvine. "New leads for liver disease treatments: Strict genomic partitioning by biological clock separates key metabolic functions." ScienceDaily. www.sciencedaily.com/releases/2014/07/140731145931.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins