Featured Research

from universities, journals, and other organizations

Graphene 'droplets' open up possibilities in drug delivery, disease detection

Date:
August 5, 2014
Source:
Monash University
Summary:
A chance discovery about the 'wonder material' graphene takes it a step closer to being used in medicine and human health. Researchers in Australia have discovered that graphene oxide sheets can change structure to become liquid crystal droplets spontaneously and without any specialist equipment. With graphene droplets now easy to produce, researchers say this opens up possibilities for its use in drug delivery and disease detection.

A chance discovery about the 'wonder material' graphene -- already exciting scientists because of its potential uses in electronics, energy storage and energy generation -- takes it a step closer to being used in medicine and human health.

Researchers from Monash University have discovered that graphene oxide sheets can change structure to become liquid crystal droplets spontaneously and without any specialist equipment.

With graphene droplets now easy to produce, researchers say this opens up possibilities for its use in drug delivery and disease detection.

The findings, published in the journal ChemComm, build on existing knowledge about graphene. One of the thinnest and strongest materials known to man, graphene is a 2D sheet of carbon just one atom thick. With a 'honeycomb' structure the 'wonder material' is 100 times stronger than steel, highly conductive and flexible.

Dr Mainak Majumder from the Faculty of Engineering said because graphene droplets change their structure in response to the presence of an external magnetic field, it could be used for controlled drug release applications.

"Drug delivery systems tend to use magnetic particles which are very effective but they can't always be used because these particles can be toxic in certain physiological conditions," Dr Majumder said.

"In contrast, graphene doesn't contain any magnetic properties. This combined with the fact that we have proved it can be changed into liquid crystal simply and cheaply, strengthens the prospect that it may one day be used for a new kind of drug delivery system."

Usually atomisers and mechanical equipment are needed to change graphene into a spherical form. In this case all the team did was to put the graphene sheets in a solution to process it for industrial use. Under certain pH conditions they found that graphene behaves like a polymer -- changing shape by itself.

First author of the paper, Ms Rachel Tkacz from the Faculty of Engineering, said the surprise discovery happened during routine tests.

"To be able to spontaneously change the structure of graphene from single sheets to a spherical assembly is hugely significant. No one thought that was possible. We've proved it is," Ms Tkacz said.

"Now we know that graphene-based assemblies can spontaneously change shape under certain conditions, we can apply this knowledge to see if it changes when exposed to toxins, potentially paving the way for new methods of disease detection as well."

Commonly used by jewelers, the team used an advanced version of a polarised light microscope based at the Marine Biological Laboratory, USA, to detect minute changes to grapheme.

Dr Majumder said collaborating with researchers internationally and accessing some of the most sophisticated equipment in the world, was instrumental to the breakthrough discovery.

"We used microscopes similar to the ones jewelers use to see the clarity of precious gems. The only difference is the ones we used are much more precise due to a sophisticated system of hardware and software. This provides us with crucial information about the organisation of graphene sheets, enabling us to recognise these unique structures," Dr Majumder said.

Dr Majumder and his team are working with graphite industry partner, Strategic Energy Resources Ltd and an expert in polarized light imaging, Dr. Rudolf Oldenbourg from the Marine Biological Laboratory, USA, to explore how this work can be translated and commercialised.

The research was made possible by an ARC Linkage grant awarded to Strategic Energy Resources Ltd and Monash University and was the first linkage grant for graphene research in Australia.

"We are so pleased to be associated with Dr Majumder's team at Monash university. The progress they have made with our joint project has been astonishing," he said.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rachel Tkacz, Rudolf Oldenbourg, Shalin B. Mehta, Morteza Miansari, Amitabh Verma, Mainak Majumder. pH dependent isotropic to nematic phase transitions in graphene oxide dispersions reveal droplet liquid crystalline phases. Chemical Communications, 2014; 50 (50): 6668 DOI: 10.1039/C4CC00970C

Cite This Page:

Monash University. "Graphene 'droplets' open up possibilities in drug delivery, disease detection." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805132007.htm>.
Monash University. (2014, August 5). Graphene 'droplets' open up possibilities in drug delivery, disease detection. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/08/140805132007.htm
Monash University. "Graphene 'droplets' open up possibilities in drug delivery, disease detection." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805132007.htm (accessed October 20, 2014).

Share This



More Matter & Energy News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gulfstream G500, G600 Unveiling

Gulfstream G500, G600 Unveiling

Flying (Oct. 20, 2014) Watch Gulfstream's public launch of the G500 and G600 at their headquarters in Savannah, Ga., along with a surprise unveiling of the G500, which taxied up under its own power. Video provided by Flying
Powered by NewsLook.com
Japanese Scientists Unveil Floating 3D Projection

Japanese Scientists Unveil Floating 3D Projection

Reuters - Innovations Video Online (Oct. 20, 2014) Scientists in Tokyo have demonstrated what they say is the world's first 3D projection that floats in mid air. A laser that fires a pulse up to a thousand times a second superheats molecules in the air, creating a spark which can be guided to certain points in the air to shape what the human eye perceives as an image. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-Fuel Impala

Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-Fuel Impala

3BL Media (Oct. 20, 2014) Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-fuel Impala Video provided by 3BL
Powered by NewsLook.com
What We Know About Microsoft's Rumored Smartwatch

What We Know About Microsoft's Rumored Smartwatch

Newsy (Oct. 20, 2014) Microsoft will reportedly release a smartwatch that works across different mobile platforms, has a two-day battery life and tracks heart rate. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins