Featured Research

from universities, journals, and other organizations

'Treatments waiting to be discovered' inside new database

Date:
August 5, 2014
Source:
University of Colorado Cancer Center
Summary:
A database named multiMiR has been described in a new article. It is the most comprehensive database collecting information about microRNAs and their targets, researchers report. In addition to assisting researchers search for relationships between microRNAs and their genetic targets, the database includes drugs known to affect these microRNAs and also lists diseases associated with microRNAs.

Your genes are blueprints for proteins, and molecules called microRNA can help to determine how often these genetic blueprints are manufactured into proteins. Researchers often ask what microRNA regulates a gene related to disease. Or what gene is regulated by a microRNA found in sick patients? The answers to these questions could help doctors and researchers manipulate protein levels in the body that cause disease, especially cancer. A University of Colorado Cancer Center study recently published in the top-ranked journal Nucleic Acids Research (NAR) describes a database named multiMiR, the most comprehensive database collecting information about microRNAs and their targets.

Related Articles


"You can't imagine the tangled web of data that describes the cause and effect relationships of microRNAs and genes. This multiMiR database will let researchers search efficiently through these relationships for pairings relevant to the diseases they study," says Katerina Kechris, PhD, associate professor of Biostatistics and Informatics at the University of Colorado Denver, and one of the study's senior authors.

In addition to assisting researchers search for relationships between microRNAs and their genetic targets, the database includes drugs known to affect these microRNAs and also lists diseases associated with microRNAs.

"Right now, within this database, investigators can find clues to potential new treatments for various diseases including cancer," says Dan Theodorescu, MD, PhD, professor of Surgery and Pharmacology at the CU School of Medicine, director of the University of Colorado Cancer Center and one of the study's senior authors.

The project includes nearly 50 million records representing the combination of 14 previously existing microRNA data repositories. The multiMiR database also links to previous research results relevant to these microRNAs. multiMiR combines this functionality within the leading open-source statistical software, R, allowing for increased flexibility for analysis and accessibility by data analysts everywhere.

Basically, researchers can input names of microRNAs, genes, drugs, diseases or any combination thereof. Then the researcher can ask the database for validated or predicted genetic targets of microRNAs, or for validated/predicted microRNAs that regulate specific genes. Similar is true of diseases and drugs -- informatics tools show which diseases are associated with microRNAs and which (if any) drugs have been linked to a specific miRNA queried.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA:gene interactions that influence bladder cancer.

"We need data and then we need clever ways to look at it otherwise we drown in the wealth of information," Theodorescu says. "This new tool will allow us to ask new questions of more data with greater precision and get better, more insightful results that will ultimately help develop new approaches for patient treatment."


Story Source:

The above story is based on materials provided by University of Colorado Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Ru, K. J. Kechris, B. Tabakoff, P. Hoffman, R. A. Radcliffe, R. Bowler, S. Mahaffey, S. Rossi, G. A. Calin, L. Bemis, D. Theodorescu. The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Research, 2014; DOI: 10.1093/nar/gku631

Cite This Page:

University of Colorado Cancer Center. "'Treatments waiting to be discovered' inside new database." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805150652.htm>.
University of Colorado Cancer Center. (2014, August 5). 'Treatments waiting to be discovered' inside new database. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2014/08/140805150652.htm
University of Colorado Cancer Center. "'Treatments waiting to be discovered' inside new database." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805150652.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins