Featured Research

from universities, journals, and other organizations

Vaccines can cut spread of meningitis by nearly 40 percent

Date:
August 18, 2014
Source:
University of Southampton
Summary:
Two new vaccines can prevent the transmission of meningitis bacteria from person to person, scientists report. The vaccines do this by reducing 'carriage' of the responsible bacteria in the nose and throats of the population. Meningitis is a devastating condition, and the research team believes this discovery will change the way new vaccines are made in the future.

Investigators at the University of Southampton have discovered that two new vaccines can prevent the transmission of meningitis bacteria from person to person.

The vaccines do this by reducing 'carriage' of the responsible bacteria in the nose and throats of the population.

Meningitis is a devastating condition and the Southampton team believe this discovery will change the way new vaccines are made in the future.

Robert Read, Professor of Infectious Diseases at the University of Southampton, who led the study, says: "The standard practice is to vaccinate with the aim of inducing high levels of antibodies in the blood to protect against the disease, but we know that these antibodies can disappear over the course of a few months.

"This study is telling us that the vaccines also have an effect on carriage in the throat and explains why they can be so effective across the population."

The study, published in The Lancet, took place over 10 centres across the UK and tested the effectiveness of two meningitis vaccines -- MenACWY-CRM and 4CMenB -- on participants aged 18 to 24 years old.

Participants were either given two doses of a control vaccine, two doses of the 4CMenB vaccine or one dose of MenACWY-CRM and then a placebo.

MenACWY-CRM was shown to reduce carriage rates by 39 per cent while the 4CMenB vaccine, which was recently approved by the Joint Committee on Vaccination and Immunisation (JCVI) in March, reduced carriage rates by between 20 and 30 per cent.

Meningitis is an infection of the meninges -- the membrane that surrounds the brain and spinal cord. Meningococcal bacteria are common and carried harmlessly in the nose or throat by about one in 10 people and are passed on through close contact. Anyone can get meningitis, but babies and young children are most vulnerable.

Professor Read adds: "This is a significant piece of work in helping more and more people be protected from meningitis. We have shown that vaccines modify the way the bacteria are carried, so even when the antibodies are no longer present in the blood, the carriage in the throat is still prevented, and so is onward transmission of the infection to others. This could provide a degree of herd protection against meningitis if implemented in a campaign in which high transmission occurs, for example in teenagers and young adults."


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert C Read, David Baxter, David R Chadwick, Saul N Faust, Adam Finn, Stephen B Gordon, Paul T Heath, David J M Lewis, Andrew J Pollard, David P J Turner, Rohit Bazaz, Amitava Ganguli, Tom Havelock, Keith R Neal, Ifeanyichukwu O Okike, Begonia Morales-Aza, Kamlesh Patel, Matthew D Snape, John Williams, Stefanie Gilchrist, Steve J Gray, Martin C J Maiden, Daniela Toneatto, Huajun Wang, Maggie McCarthy, Peter M Dull, Ray Borrow. Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial. The Lancet, 2014; DOI: 10.1016/S0140-6736(14)60842-4

Cite This Page:

University of Southampton. "Vaccines can cut spread of meningitis by nearly 40 percent." ScienceDaily. ScienceDaily, 18 August 2014. <www.sciencedaily.com/releases/2014/08/140818204116.htm>.
University of Southampton. (2014, August 18). Vaccines can cut spread of meningitis by nearly 40 percent. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/08/140818204116.htm
University of Southampton. "Vaccines can cut spread of meningitis by nearly 40 percent." ScienceDaily. www.sciencedaily.com/releases/2014/08/140818204116.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins