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How To Identify Early Graft Dysfunction Preoperatively

October 16, 2009
World Journal of Gastroenterology
A research team from Italy described a condition that they define as early graft dysfunction (EGD) which can be identified preoperatively. They found EGD is associated with increased morbidity after living-related liver transplantation.

Small-for-size graft dysfunction (SFSGD) following living-related liver transplantation (LRLT) is characterized by early graft dysfunction (EGD) when the graft-to-recipient body weight ratio (GRBWR) is below 0.8%. However, patients transplanted with GRBWR above 0.8% can develop dysfunction of the graft.

A research team, led by Dr. Salvatore Gruttadauria from University of Pittsburgh analyzed a group of LRLT recipients in order to identify those who developed a clinical picture of SFSGD in the absence of a GBWR of < 0.8% and with a ratio of graft volume (GV) relative to the standard liver volume (SLV) of the recipient (GV/SLV) highest than 30%. Those patients were defined as affected by early graft dysfunction (EGD).

Their study will be published on September 28, 2009 in the World Journal of Gastroenterology.

In this study, a trend in favor of the non-EGD group (3-mo actuarial survival 98% vs 88%, P = 0.09; 3-mo graft mortality 4.7% vs 20%, P = 0.07) was observed as well as shorter length of stay (LOS) (13 d vs 41.5 d; P = 0.001) and smaller requirement of peri-operative Units of Plasma (4 vs 14; P = 0.036). Univariate analysis of pre-transplant variables identified platelet count, serum bilirubin, INR and Meld-Na score as predictors of EGD. In the multivariate analysis transplant Meld-Na score (P = 0.025, OR: 1.175) and pre-transplant platelet count (P = 0.043, OR: 0.956) were independently associated with EGD.

They drew a conclusion that a prompt recognition of EGD can trigger a timely and appropriate treatment.

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Materials provided by World Journal of Gastroenterology. Note: Content may be edited for style and length.

Journal Reference:

  1. Gruttadauria S, di Francesco F, Vizzini GB, Luca A, Spada M, Cintorino D, Li Petri S, Pietrosi G, Pagano D, Gridelli B. Early graft dysfunction following adult-to-adult living-related liver transplantation: Predictive factors and outcomes. World Journal of Gastroenterology, 2009; 15 (36): 4556 DOI: 10.3748/wjg.15.4556

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World Journal of Gastroenterology. "How To Identify Early Graft Dysfunction Preoperatively." ScienceDaily. ScienceDaily, 16 October 2009. <>.
World Journal of Gastroenterology. (2009, October 16). How To Identify Early Graft Dysfunction Preoperatively. ScienceDaily. Retrieved July 25, 2024 from
World Journal of Gastroenterology. "How To Identify Early Graft Dysfunction Preoperatively." ScienceDaily. (accessed July 25, 2024).

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