Researchers from The Scripps Research Institute (TSRI) have found that physical exercise may be a useful technique to reduce methamphetamine use. Drs. Shawn M. Aarde and Michael A. Taffe used a preclinical model in which male rats are trained to press a lever to obtain intravenous infusions of methamphetamine. Prior work had shown that an extended interval (6 weeks) of voluntary activity on a running wheel could reduce cocaine self-administration in laboratory rats. The investigators now report that running wheel access in only the 22 hours prior to the test session is sufficient to significantly reduce the amount of methamphetamine self-administered. Thus, this study shows that it may not require 6 weeks of chronic activity to produce a beneficial effect on drug use.

The finding has important implications for using exercise as an adjunct to human drug cessation therapy because an extended interval of continual physical activity may not be required; effects may be seen immediately. An additional study presented by the team shows that rats' self-administration of the drug known as "Ecstasy" or "Molly" (±3,4-methylenedioxymethampetamine, MDMA) is also decreased in animals who have access to a wheel in their home cages.

Dr. Taffe presented the findings during the Experimental Biology 2014 meeting on Sunday, April 27, 2014.

The study was funded by the U.S. Public Health Service.

Story Source:

Materials provided by Federation of American Societies for Experimental Biology (FASEB). Note: Content may be edited for style and length.