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Study identifies risk factors linking low birthweight to diabetes

Date:
January 5, 2015
Source:
Brown University
Summary:
Low birth weight predicts an increased risk of type 2 diabetes in adulthood, s new study of more than 3,000 women confirms. It also identifies which intermediating biomarkers appear to be the best predictors. The research could help physicians better assess patient risk.
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Low birthweight points to a higher risk of adult-onset type 2 diabetes. A number of related factors could alert physicians to a greater likelihood that a patient who had low birthweight is at greater risk.
Credit: Liu lab/Brown University

Studies consistently show that people born weighing 6 pounds or less face an increased risk for type 2 diabetes as adults. A new study not only confirms that risk in a sample of more than 3,000 women but also shows the relative predictive value of different biomarkers, giving doctors potential new tools for understanding individual risk among low birthweight women.

The findings also could help guide researchers trying to tease out which physiological processes might be sent awry by low-birth weight, ultimately leading to type 2 diabetes.

"We are trying to understand what proportion of the risk attributable to low birthweight can indeed be explained by these biochemical intermediates, to understand the relative importance of each pathway," said study senior author Dr. Simin Liu, professor of epidemiology and medicine at Brown University.

The research, published in the journal Diabetologia, drew on the detailed health records of participants in the Women's Health Initiative, a huge study supported by the National Heart Lung and Blood Institute. Liu's team focused on 1,259 women who developed type 2 diabetes and 1,790 otherwise similar women who did not.

Overall the data showed that low birthweight (less than 6 pounds) portended a 2.15 times greater risk of developing type 2 diabetes compared to women born between 8 and 10 pounds. This risk calculation adjusted for a variety of other possible confounding variables such as smoking, drinking, exercise, diet, body-mass index, race, ethnicity, and family history of diabetes. Compared to women born between 6 and 8 pounds, low birthweight women had a risk that was 1.27 times greater.

The study also looked at the relative predictive value, measured in percentages, of various readily measurable biomarkers. Among them insulin resistance contributed most strongly (accounting for 47 percent), which is not surprising because insulin resistance is a core component of diabetes. High levels of E-selectin, a marker of problems with blood vessel lining, accounted for 25 percent, low levels of sex-hormone binding globulin contributed 24 percent, and high systolic blood pressure's mediation emerged at 8 percent from the statistical analysis.

Each of these calculations also controlled for potential confounding variables. Percentages do not add to 100 because some pathways of the risk factors may overlap.

Liu and his co-authors, including lead author Dr. Yan Song a visiting postdoctoral fellow, said they hope the findings will give doctors a refined understanding of relative risk among low birthweight women.

"These prospective data provide quantifiable mechanistic evidence linking low birthweight to increased risk of type 2 diabetes, while presenting risk stratification in a population at greater risk of developing type 2 diabetes later in life," they conclude.


Story Source:

Materials provided by Brown University. Note: Content may be edited for style and length.


Journal Reference:

  1. Simin Liu et al. Birthweight, mediating biomarkers and the development of type 2 diabetes later in life: a prospective study of multi-ethnic women. Diabetologia, December 2014 DOI: 10.1007/s00125-014-3479-2

Cite This Page:

Brown University. "Study identifies risk factors linking low birthweight to diabetes." ScienceDaily. ScienceDaily, 5 January 2015. <www.sciencedaily.com/releases/2015/01/150105112418.htm>.
Brown University. (2015, January 5). Study identifies risk factors linking low birthweight to diabetes. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/01/150105112418.htm
Brown University. "Study identifies risk factors linking low birthweight to diabetes." ScienceDaily. www.sciencedaily.com/releases/2015/01/150105112418.htm (accessed May 23, 2017).

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