Break on through to the other side: How HIV penetrates the blood-brain barrier

"I hope this study brings awareness to the need for adjunctive therapies targeting monocyte influx into the brain as a means to decrease HIV entry into the brain and HIV-associated neurocognitive disorder," said Dionna W. Williams, Ph.D., a researcher involved in the work from the Department of Pathology at the Albert Einstein College of Medicine in Bronx, New York.

To make their discovery, scientists received blood from two groups of people--people infected by HIV and people who were not infected. Mature monocytes were obtained from the blood of people from both groups and researchers determined how many of these cells were present, what proteins the cells expressed and also characterized how they entered into the brain. The researchers found that the mature monocytes had an increased ability to enter into the brain due to the unique proteins they expressed, which could lead to HIV infecting the brain.

"Monocytes are normal part of the immune system's defense against viruses, but these cells have also been known to act like 'Trojan horses' and carry viruses from the site of initial infection to other parts of the body," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Identifying how these cells facilitate HIV entry into the brain might provide new treatment opportunities not only for HIV but other neurological diseases."