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Drug research, development more efficient than expected

Date:
February 27, 2015
Source:
University of Basel
Summary:
Despite ever increasing regulation in drug approval and the rising costs of research, drug research and development remains unexpectedly efficient, a new shows. To investigate the efficiency in the development of new drugs, the researchers analyzed a data set consisting of new drugs approved by the FDA. They looked at efficiency indicators that could potentially positively influence the approval of new drugs.
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Drug R&D costs have increased substantially in recent decades, while the number of new drugs has remained fairly constant, leading to concerns about the sustainability of drug R&D and question about the factors that could be responsible.

To investigate the efficiency in the development of new drugs, the researchers analyzed a data set consisting of new drugs approved by the FDA. They looked at efficiency indicators that could potentially positively influence the approval of new drugs.

Lower costs, faster approval

The study lead by Prof. Thomas D. Szucs analyzed 257 new drugs that were approved by the FDA from 2003 to 2013. To assess the so-called innovation efficiency, the researchers analyzed specific parameters and factors. The study shows: Although there remains some potential for efficiency enhancement, several parameters have developed positively in the past decade.

The researchers also discovered that new drugs get approved earlier and with less use of resources, when they entered the approval process assigned to special categories or programs. Affiliation to these categories alone reduces for example the probability of having to conduct expensive pivotal trials -- a clinical trial designed to test the effectiveness of a drug against a placebo control group.

In conclusion the results show that market access of new drugs is not inefficient. Important is that "both industry and authorities work together in further developing drug approval in order to provide innovation to patients in a timely manner," says Szucs.


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Materials provided by University of Basel. Note: Content may be edited for style and length.


Journal Reference:

  1. Rossella Belleli, Roland Fisch, Thomas D. Szucs. Regulatory watch: Efficiency indicators for new drugs approved by the FDA from 2003 to 2013. Nature Reviews Drug Discovery, 2015; 14 (3): 156 DOI: 10.1038/nrd4563

Cite This Page:

University of Basel. "Drug research, development more efficient than expected." ScienceDaily. ScienceDaily, 27 February 2015. <www.sciencedaily.com/releases/2015/02/150227131016.htm>.
University of Basel. (2015, February 27). Drug research, development more efficient than expected. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/02/150227131016.htm
University of Basel. "Drug research, development more efficient than expected." ScienceDaily. www.sciencedaily.com/releases/2015/02/150227131016.htm (accessed May 23, 2017).

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