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Morphine test printed on paper

Date:
April 13, 2015
Source:
Technical Research Centre of Finland (VTT)
Summary:
Scientists used antibodies - produced by methods of molecular biology - as morphine sensing molecules when creating a printing technology-based morphine test. Using printing technology to manufacture rapid tests enables high production volumes and low production costs. A paper-based test enables a rapid analysis of whether a compound - in this case, morphine - is present in a given sample.
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Morphine test.
Credit: Image courtesy of Technical Research Centre of Finland (VTT)

VTT has developed a drug test printed on paper. VTT used antibodies -- produced by methods of molecular biology -- as morphine sensing molecules when creating this printing technology-based morphine test. Using printing technology to manufacture rapid tests enables high production volumes and low production costs.

A paper-based test enables a rapid analysis of whether a compound -- in this case, morphine -- is present in a given sample. Possible future applications of the developed test include drug testing at workplaces and in connection with traffic control.

This method, developed by VTT Technical Research Centre of Finland Ltd, provides several advantages, such as high production volumes, low material costs and disposability as well as design freedom based on bendability and foldability of paper.

"In 2010, we proved that the VTT method works in a hemoglobin assay. Through our continued development efforts, we wanted to confirm that the method also works in mass-production of more demanding tests. Morphine as a small-sized molecule places major requirements on the analytical performance of the test. In the future, the new method will also present an opportunity to simultaneously analyse other drugs of abuse and residues of pharmaceuticals and their metabolites from one and the same sample," says Tomi Erho, Principal Scientist at VTT.

Morphine and hemoglobin tests have shown that paper is an excellent platform for various antibody-based tests. In rapid testing, paper can replace nitrocellulose, which is typically used as a reaction and flow substrate, to provide a very low-cost, lightweight and biodegradable material alternative. In the future, paper could also become a competitive alternative for commonly used plastic-based assay platforms.

Printing technology will be a low-cost method for the manufacture of rapid tests designed for the use of consumers, businesses and authorities for instance in the areas of health, welfare and the environment.

Rapid diagnostics and the expansion of testing outside clinical and analytical laboratories to patients and other end-users is a rising trend. Printing of tests on paper will provide entirely new opportunities for innovations based on the mass production of home test kits.

The research was performed at VTT as part of research projects mainly funded by Tekes -- the Finnish Funding Agency for Innovation.


Story Source:

Materials provided by Technical Research Centre of Finland (VTT). Note: Content may be edited for style and length.


Journal Reference:

  1. Tuija Teerinen, Timo Lappalainen, Tomi Erho. A paper-based lateral flow assay for morphine. Analytical and Bioanalytical Chemistry, 2014; 406 (24): 5955 DOI: 10.1007/s00216-014-8001-7

Cite This Page:

Technical Research Centre of Finland (VTT). "Morphine test printed on paper." ScienceDaily. ScienceDaily, 13 April 2015. <www.sciencedaily.com/releases/2015/04/150413102531.htm>.
Technical Research Centre of Finland (VTT). (2015, April 13). Morphine test printed on paper. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/04/150413102531.htm
Technical Research Centre of Finland (VTT). "Morphine test printed on paper." ScienceDaily. www.sciencedaily.com/releases/2015/04/150413102531.htm (accessed May 26, 2017).

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