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Cancer scan could remove need for radiotherapy for cured patients

Date:
April 22, 2015
Source:
University of Manchester
Summary:
In patients with early stage Hodgkin lymphoma, the late effects of radiotherapy could be reduced by using a scan to determine those who actually need it, new research shows. Hodgkin lymphoma is a cancer that develops in the lymphatic system, which is a network of vessels and glands spread throughout the body.
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In a paper published in the New England Journal of Medicine, the scientists show that a positron-emission tomography (PET) scan immediately after treatment with chemotherapy can identify patients who have a very good outcome without additional radiotherapy.

Hodgkin lymphoma is a cancer that develops in the lymphatic system, which is a network of vessels and glands spread throughout the body. Around 1,900 people a year, many of whom are teenagers and young adults, are diagnosed in the UK.

The current standard treatment is for all Hodgkin lymphoma patients to receive chemotherapy, followed by radiotherapy. However, this radiotherapy comes with undesirable late effects, such as cardiovascular disease and other cancers -- despite the fact that they have already been cured of Hodgkin lymphoma.

The 602 patients who agreed to take part in the 'RAPID' trial had a PET scan performed after their chemotherapy. Patients who tested positive received radiotherapy. Those who tested negative were divided into two groups -- one group of 211 patients received no further treatment, while the other group of 209 had the standard radiotherapy.

After three years of regular check-ups, the proportion of patients who were alive and free of disease was 94.6% in the radiotherapy group, and 90.8% in the group which hadn't received further treatment.

Lead researcher, Professor John Radford, is based at The University of Manchester's Institute of Cancer Sciences and the Christie NHS Foundation Trust. He said: "This research is an important step forward. The results of RAPID show that in early stage Hodgkin lymphoma radiotherapy after initial chemotherapy marginally reduces the recurrence rate, but this is bought at the expense of exposing to radiation all patients with negative PET findings, most of whom are already cured."

Despite the findings from this study the researchers stress that a longer follow-up period is needed in order to determine whether this approach will ultimately lead to fewer late side-effects and improved overall survival.

The research was funded by Leukemia & Lymphoma Research. Dr Matt Kaiser, Head of Research at the charity, said: "This groundbreaking clinical trial shows that, by using scans to predict an individual's risk of relapse, many patients can remain disease-free with just chemotherapy alone. Radiotherapy can cause a range of long-term problems like heart disease and hard-to-treat second cancers. As many Hodgkin lymphoma patients are relatively young, it is particularly important to avoid using intensive treatment when it is unnecessary."


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Materials provided by University of Manchester. Note: Content may be edited for style and length.


Journal Reference:

  1. John Radford, Tim Illidge, Nicholas Counsell, Barry Hancock, Ruth Pettengell, Peter Johnson, Jennie Wimperis, Dominic Culligan, Bilyana Popova, Paul Smith, Andrew McMillan, Alison Brownell, Anton Kruger, Andrew Lister, Peter Hoskin, Michael O’Doherty, Sally Barrington. Results of a Trial of PET-Directed Therapy for Early-Stage Hodgkin’s Lymphoma. New England Journal of Medicine, 2015; 372 (17): 1598 DOI: 10.1056/NEJMoa1408648

Cite This Page:

University of Manchester. "Cancer scan could remove need for radiotherapy for cured patients." ScienceDaily. ScienceDaily, 22 April 2015. <www.sciencedaily.com/releases/2015/04/150422174856.htm>.
University of Manchester. (2015, April 22). Cancer scan could remove need for radiotherapy for cured patients. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2015/04/150422174856.htm
University of Manchester. "Cancer scan could remove need for radiotherapy for cured patients." ScienceDaily. www.sciencedaily.com/releases/2015/04/150422174856.htm (accessed May 28, 2017).

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